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Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection

Cytomegalovirus (CMV) is the leading cause of congenital infection. Its occurrence is phenotypically heterogeneous. The type of maternal infection, primary or non-primary, is an important factor related to the symptomatic disease, the primary infection was long considered the only cause of severe ne...

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Autores principales: Coscia, Alessandra, Leone, Agata, Rubino, Carlotta, Galitska, Ganna, Biolatti, Matteo, Bertino, Enrico, Peila, Chiara, Cresi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285369/
https://www.ncbi.nlm.nih.gov/pubmed/32466137
http://dx.doi.org/10.3390/microorganisms8050786
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author Coscia, Alessandra
Leone, Agata
Rubino, Carlotta
Galitska, Ganna
Biolatti, Matteo
Bertino, Enrico
Peila, Chiara
Cresi, Francesco
author_facet Coscia, Alessandra
Leone, Agata
Rubino, Carlotta
Galitska, Ganna
Biolatti, Matteo
Bertino, Enrico
Peila, Chiara
Cresi, Francesco
author_sort Coscia, Alessandra
collection PubMed
description Cytomegalovirus (CMV) is the leading cause of congenital infection. Its occurrence is phenotypically heterogeneous. The type of maternal infection, primary or non-primary, is an important factor related to the symptomatic disease, the primary infection was long considered the only cause of severe neonatal disease. We aimed to analyze the association of primary and non-primary infection with pathological outcomes in infants and with long-term sequelae at follow-up. This was a monocentric retrospective observational study on a population of 91 infants diagnosed with a CMV infection at the Neonatal Care Unit of Neonatology at the Sant’Anna Hospital of Turin during the period of June 2005 to December 2018. Infants underwent clinical, laboratory, and neuroradiological evaluations at birth. Subsequently, the patients were monitored in an auxological, neurodevelopment, and audiological follow-up. Regarding primary vs. non-primary infection, we found a higher percentage of incidence of symptomatic and neurological localized infection, as well as long-term sequelae in the latter. However, no significant difference between the two populations was found. We underline the possibility of re-infection in previously immunized mothers (non-primary infection) with unfavorable neonatal and long-term outcomes.
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spelling pubmed-72853692020-06-17 Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection Coscia, Alessandra Leone, Agata Rubino, Carlotta Galitska, Ganna Biolatti, Matteo Bertino, Enrico Peila, Chiara Cresi, Francesco Microorganisms Communication Cytomegalovirus (CMV) is the leading cause of congenital infection. Its occurrence is phenotypically heterogeneous. The type of maternal infection, primary or non-primary, is an important factor related to the symptomatic disease, the primary infection was long considered the only cause of severe neonatal disease. We aimed to analyze the association of primary and non-primary infection with pathological outcomes in infants and with long-term sequelae at follow-up. This was a monocentric retrospective observational study on a population of 91 infants diagnosed with a CMV infection at the Neonatal Care Unit of Neonatology at the Sant’Anna Hospital of Turin during the period of June 2005 to December 2018. Infants underwent clinical, laboratory, and neuroradiological evaluations at birth. Subsequently, the patients were monitored in an auxological, neurodevelopment, and audiological follow-up. Regarding primary vs. non-primary infection, we found a higher percentage of incidence of symptomatic and neurological localized infection, as well as long-term sequelae in the latter. However, no significant difference between the two populations was found. We underline the possibility of re-infection in previously immunized mothers (non-primary infection) with unfavorable neonatal and long-term outcomes. MDPI 2020-05-25 /pmc/articles/PMC7285369/ /pubmed/32466137 http://dx.doi.org/10.3390/microorganisms8050786 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Coscia, Alessandra
Leone, Agata
Rubino, Carlotta
Galitska, Ganna
Biolatti, Matteo
Bertino, Enrico
Peila, Chiara
Cresi, Francesco
Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title_full Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title_fullStr Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title_full_unstemmed Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title_short Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection
title_sort risk of symptomatic infection after non-primary congenital cytomegalovirus infection
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285369/
https://www.ncbi.nlm.nih.gov/pubmed/32466137
http://dx.doi.org/10.3390/microorganisms8050786
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