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The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic

We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species...

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Autores principales: Ortiz Moyano, Ramiro, Raya Tonetti, Fernanda, Tomokiyo, Mikado, Kanmani, Paulraj, Vizoso-Pinto, María Guadalupe, Kim, Hojun, Quilodrán-Vega, Sandra, Melnikov, Vyacheslav, Alvarez, Susana, Takahashi, Hideki, Kurata, Shoichiro, Kitazawa, Haruki, Villena, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285514/
https://www.ncbi.nlm.nih.gov/pubmed/32414154
http://dx.doi.org/10.3390/microorganisms8050727
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author Ortiz Moyano, Ramiro
Raya Tonetti, Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso-Pinto, María Guadalupe
Kim, Hojun
Quilodrán-Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio
author_facet Ortiz Moyano, Ramiro
Raya Tonetti, Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso-Pinto, María Guadalupe
Kim, Hojun
Quilodrán-Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio
author_sort Ortiz Moyano, Ramiro
collection PubMed
description We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
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spelling pubmed-72855142020-06-17 The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic Ortiz Moyano, Ramiro Raya Tonetti, Fernanda Tomokiyo, Mikado Kanmani, Paulraj Vizoso-Pinto, María Guadalupe Kim, Hojun Quilodrán-Vega, Sandra Melnikov, Vyacheslav Alvarez, Susana Takahashi, Hideki Kurata, Shoichiro Kitazawa, Haruki Villena, Julio Microorganisms Article We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract. MDPI 2020-05-13 /pmc/articles/PMC7285514/ /pubmed/32414154 http://dx.doi.org/10.3390/microorganisms8050727 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ortiz Moyano, Ramiro
Raya Tonetti, Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso-Pinto, María Guadalupe
Kim, Hojun
Quilodrán-Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio
The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_full The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_fullStr The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_full_unstemmed The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_short The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_sort ability of respiratory commensal bacteria to beneficially modulate the lung innate immune response is a strain dependent characteristic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285514/
https://www.ncbi.nlm.nih.gov/pubmed/32414154
http://dx.doi.org/10.3390/microorganisms8050727
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