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Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

BACKGROUND: A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is associated with the antidepressant effects of ketamine and the interaction betw...

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Detalles Bibliográficos
Autores principales:	Tang, Xiao-Hui, Zhang, Guang-Fen, Xu, Ning, Duan, Gui-Fang, Jia, Min, Liu, Ru, Zhou, Zhi-Qiang, Yang, Jian-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285526/ https://www.ncbi.nlm.nih.gov/pubmed/32522211 http://dx.doi.org/10.1186/s12974-020-01843-z

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