Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging

BACKGROUND: Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research. METHODS: We performed a whole-genome sequencing in 19 centenarians to...

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Detalles Bibliográficos
Autores principales: Shen, Shuhua, Li, Chao, Xiao, Luwei, Wang, Xiaoming, Lv, Hang, Shi, Yuan, Li, Yixue, Huang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285530/
https://www.ncbi.nlm.nih.gov/pubmed/32522283
http://dx.doi.org/10.1186/s40246-020-00271-7
Descripción
Sumario:BACKGROUND: Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research. METHODS: We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity. RESULTS: Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overrepresented. CONCLUSIONS: Our study indicated a new mechanism of longevity, suggesting potential genetic variants for further study.

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