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Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study
BACKGROUND: Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density and strength in older people recovering from a hip fracture. METHODS: A tota...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285571/ https://www.ncbi.nlm.nih.gov/pubmed/32517755 http://dx.doi.org/10.1186/s12891-020-03401-3 |
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author | Suominen, Tuuli H. Edgren, Johanna Salpakoski, Anu Kallinen, Mauri Cervinka, Tomas Rantalainen, Timo Törmäkangas, Timo Heinonen, Ari Sipilä, Sarianna |
author_facet | Suominen, Tuuli H. Edgren, Johanna Salpakoski, Anu Kallinen, Mauri Cervinka, Tomas Rantalainen, Timo Törmäkangas, Timo Heinonen, Ari Sipilä, Sarianna |
author_sort | Suominen, Tuuli H. |
collection | PubMed |
description | BACKGROUND: Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density and strength in older people recovering from a hip fracture. METHODS: A total of 81 over 60-year-old, community-dwelling men and women operated for a hip fracture participated in this 1-year prospective follow-up study. Distal tibia total volumetric bone mineral density (vBMD(TOT), mg/cm(3)) and compressive strength index (BSI, g(2)/cm(4)) and mid-tibia cortical vBMD (vBMD(CO), mg/cm(3)) and bending strength index (SSI, mm(3)) were assessed in both legs by peripheral quantitative computed tomography (pQCT) at baseline (on average 10 weeks after fracture) and at 12 months. At baseline, LBM was measured with a bioimpedance device and physical function with the Short Physical Performance Battery (SPPB) and perceived difficulty in walking outdoors. Robust multivariable linear regression models were used to estimate the associations of physical function and LBM with the change in bone parameters at 12-months. RESULTS: The mean change in distal tibia vBMD(TOT) and BSI in both legs ranged from − 0.9 to − 2.5%. The change in mid-tibia vBMD(CO) and SSI ranged from − 0.5 to − 2.1%. A lower SPPB score, difficulty in walking outdoors and lower LBM predicted greater decline in distal tibia vBMD(TOT) in both legs. A lower SPPB score and difficulty in walking outdoors were also associated with a greater decline in distal tibia BSI in both legs. At the midshaft site, a lower SPPB score and lower LBM were associated with greater decline in SSI on the fractured side. CONCLUSIONS: Older hip fracture patients with low physical function and lower LBM may be at risk for greater decline in tibia bone properties during the first post-fracture year. Acknowledgement of the risk factors could assist in developing interventions and care to promote bone health and overall recovery. TRIAL REGISTRATION: ISRCTN, ISRCTN53680197. The trial was registered retrospectively but before the recruitment was completed. Registered March 3, 2010. |
format | Online Article Text |
id | pubmed-7285571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72855712020-06-10 Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study Suominen, Tuuli H. Edgren, Johanna Salpakoski, Anu Kallinen, Mauri Cervinka, Tomas Rantalainen, Timo Törmäkangas, Timo Heinonen, Ari Sipilä, Sarianna BMC Musculoskelet Disord Research Article BACKGROUND: Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density and strength in older people recovering from a hip fracture. METHODS: A total of 81 over 60-year-old, community-dwelling men and women operated for a hip fracture participated in this 1-year prospective follow-up study. Distal tibia total volumetric bone mineral density (vBMD(TOT), mg/cm(3)) and compressive strength index (BSI, g(2)/cm(4)) and mid-tibia cortical vBMD (vBMD(CO), mg/cm(3)) and bending strength index (SSI, mm(3)) were assessed in both legs by peripheral quantitative computed tomography (pQCT) at baseline (on average 10 weeks after fracture) and at 12 months. At baseline, LBM was measured with a bioimpedance device and physical function with the Short Physical Performance Battery (SPPB) and perceived difficulty in walking outdoors. Robust multivariable linear regression models were used to estimate the associations of physical function and LBM with the change in bone parameters at 12-months. RESULTS: The mean change in distal tibia vBMD(TOT) and BSI in both legs ranged from − 0.9 to − 2.5%. The change in mid-tibia vBMD(CO) and SSI ranged from − 0.5 to − 2.1%. A lower SPPB score, difficulty in walking outdoors and lower LBM predicted greater decline in distal tibia vBMD(TOT) in both legs. A lower SPPB score and difficulty in walking outdoors were also associated with a greater decline in distal tibia BSI in both legs. At the midshaft site, a lower SPPB score and lower LBM were associated with greater decline in SSI on the fractured side. CONCLUSIONS: Older hip fracture patients with low physical function and lower LBM may be at risk for greater decline in tibia bone properties during the first post-fracture year. Acknowledgement of the risk factors could assist in developing interventions and care to promote bone health and overall recovery. TRIAL REGISTRATION: ISRCTN, ISRCTN53680197. The trial was registered retrospectively but before the recruitment was completed. Registered March 3, 2010. BioMed Central 2020-06-09 /pmc/articles/PMC7285571/ /pubmed/32517755 http://dx.doi.org/10.1186/s12891-020-03401-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Suominen, Tuuli H. Edgren, Johanna Salpakoski, Anu Kallinen, Mauri Cervinka, Tomas Rantalainen, Timo Törmäkangas, Timo Heinonen, Ari Sipilä, Sarianna Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title | Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title_full | Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title_fullStr | Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title_full_unstemmed | Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title_short | Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
title_sort | physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285571/ https://www.ncbi.nlm.nih.gov/pubmed/32517755 http://dx.doi.org/10.1186/s12891-020-03401-3 |
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