The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs

N(6)-methyladenosine (m(6)A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m(6)A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m(6)A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m(6)A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field.