The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs

N(6)-methyladenosine (m(6)A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism...

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Autores principales: Zhang, Lele, Hou, Chaofeng, Chen, Chen, Guo, Yaxin, Yuan, Weitang, Yin, Detao, Liu, Jinbo, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285594/
https://www.ncbi.nlm.nih.gov/pubmed/32522202
http://dx.doi.org/10.1186/s12943-020-01224-3
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author Zhang, Lele
Hou, Chaofeng
Chen, Chen
Guo, Yaxin
Yuan, Weitang
Yin, Detao
Liu, Jinbo
Sun, Zhenqiang
author_facet Zhang, Lele
Hou, Chaofeng
Chen, Chen
Guo, Yaxin
Yuan, Weitang
Yin, Detao
Liu, Jinbo
Sun, Zhenqiang
author_sort Zhang, Lele
collection PubMed
description N(6)-methyladenosine (m(6)A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m(6)A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m(6)A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m(6)A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field.
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spelling pubmed-72855942020-06-10 The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs Zhang, Lele Hou, Chaofeng Chen, Chen Guo, Yaxin Yuan, Weitang Yin, Detao Liu, Jinbo Sun, Zhenqiang Mol Cancer Review N(6)-methyladenosine (m(6)A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently closed RNA molecules characterized by universality, diversity, stability and conservatism of evolution. Accumulating evidence shows that both m(6)A modification and circRNAs participate in the pathogenesis of multiple diseases, such as cancers, neurological diseases, autoimmune diseases, and infertility. Recently, m(6)A modification has been identified for its enrichment and vital biological functions in regulating circRNAs. In this review, we summarize the role of m(6)A modification in the regulation and function of circRNAs. Moreover, we discuss the potential applications and possible future directions in the field. BioMed Central 2020-06-10 /pmc/articles/PMC7285594/ /pubmed/32522202 http://dx.doi.org/10.1186/s12943-020-01224-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Lele
Hou, Chaofeng
Chen, Chen
Guo, Yaxin
Yuan, Weitang
Yin, Detao
Liu, Jinbo
Sun, Zhenqiang
The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title_full The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title_fullStr The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title_full_unstemmed The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title_short The role of N(6)-methyladenosine (m(6)A) modification in the regulation of circRNAs
title_sort role of n(6)-methyladenosine (m(6)a) modification in the regulation of circrnas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285594/
https://www.ncbi.nlm.nih.gov/pubmed/32522202
http://dx.doi.org/10.1186/s12943-020-01224-3
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