Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

BACKGROUND: The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer’s disease (LOAD). Research on APOE4 has mainly focu...

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Detalles Bibliográficos
Autores principales: Larramona-Arcas, Raquel, González-Arias, Candela, Perea, Gertrudis, Gutiérrez, Antonia, Vitorica, Javier, García-Barrera, Tamara, Gómez-Ariza, José Luis, Pascua-Maestro, Raquel, Ganfornina, María Dolores, Kara, Eleanna, Hudry, Eloise, Martinez-Vicente, Marta, Vila, Miquel, Galea, Elena, Masgrau, Roser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285605/
https://www.ncbi.nlm.nih.gov/pubmed/32517777
http://dx.doi.org/10.1186/s13024-020-00382-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285605/
https://www.ncbi.nlm.nih.gov/pubmed/32517777
http://dx.doi.org/10.1186/s13024-020-00382-8

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