The usefulness of lactate dehydrogenase measurements in current oncological practice

One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), w...

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Autores principales: Forkasiewicz, Agata, Dorociak, Maja, Stach, Kamilla, Szelachowski, Piotr, Tabola, Renata, Augoff, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Invited Review Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285607/
https://www.ncbi.nlm.nih.gov/pubmed/32528540
http://dx.doi.org/10.1186/s11658-020-00228-7
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author Forkasiewicz, Agata
Dorociak, Maja
Stach, Kamilla
Szelachowski, Piotr
Tabola, Renata
Augoff, Katarzyna
author_facet Forkasiewicz, Agata
Dorociak, Maja
Stach, Kamilla
Szelachowski, Piotr
Tabola, Renata
Augoff, Katarzyna
author_sort Forkasiewicz, Agata
collection PubMed
description One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects of cancer treatment. The aim of this review is to summarize the current knowledge about methods and the practical utility for measuring both the total LDH and LDH isoenzymatic activities in the diagnosis, prognosis and prediction of cancer diseases.
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spelling pubmed-72856072020-06-10 The usefulness of lactate dehydrogenase measurements in current oncological practice Forkasiewicz, Agata Dorociak, Maja Stach, Kamilla Szelachowski, Piotr Tabola, Renata Augoff, Katarzyna Cell Mol Biol Lett Invited Review Letter One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects of cancer treatment. The aim of this review is to summarize the current knowledge about methods and the practical utility for measuring both the total LDH and LDH isoenzymatic activities in the diagnosis, prognosis and prediction of cancer diseases. BioMed Central 2020-06-09 /pmc/articles/PMC7285607/ /pubmed/32528540 http://dx.doi.org/10.1186/s11658-020-00228-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Invited Review Letter
Forkasiewicz, Agata
Dorociak, Maja
Stach, Kamilla
Szelachowski, Piotr
Tabola, Renata
Augoff, Katarzyna
The usefulness of lactate dehydrogenase measurements in current oncological practice
title The usefulness of lactate dehydrogenase measurements in current oncological practice
title_full The usefulness of lactate dehydrogenase measurements in current oncological practice
title_fullStr The usefulness of lactate dehydrogenase measurements in current oncological practice
title_full_unstemmed The usefulness of lactate dehydrogenase measurements in current oncological practice
title_short The usefulness of lactate dehydrogenase measurements in current oncological practice
title_sort usefulness of lactate dehydrogenase measurements in current oncological practice
topic Invited Review Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285607/
https://www.ncbi.nlm.nih.gov/pubmed/32528540
http://dx.doi.org/10.1186/s11658-020-00228-7
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