PTENP1 is a ceRNA for PTEN: it’s CRISPR clear

Here we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect competing endo...

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Autores principales: Vitiello, Marianna, Evangelista, Monica, Zhang, Yang, Salmena, Leonardo, Pandolfi, Pier Paolo, Poliseno, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285706/
https://www.ncbi.nlm.nih.gov/pubmed/32517731
http://dx.doi.org/10.1186/s13045-020-00894-2
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author Vitiello, Marianna
Evangelista, Monica
Zhang, Yang
Salmena, Leonardo
Pandolfi, Pier Paolo
Poliseno, Laura
author_facet Vitiello, Marianna
Evangelista, Monica
Zhang, Yang
Salmena, Leonardo
Pandolfi, Pier Paolo
Poliseno, Laura
author_sort Vitiello, Marianna
collection PubMed
description Here we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect competing endogenous RNA (ceRNA)-based interactions, while providing further experimental evidence in support of the very first one that we discovered.
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spelling pubmed-72857062020-06-11 PTENP1 is a ceRNA for PTEN: it’s CRISPR clear Vitiello, Marianna Evangelista, Monica Zhang, Yang Salmena, Leonardo Pandolfi, Pier Paolo Poliseno, Laura J Hematol Oncol Rapid Communication Here we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect competing endogenous RNA (ceRNA)-based interactions, while providing further experimental evidence in support of the very first one that we discovered. BioMed Central 2020-06-09 /pmc/articles/PMC7285706/ /pubmed/32517731 http://dx.doi.org/10.1186/s13045-020-00894-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Rapid Communication
Vitiello, Marianna
Evangelista, Monica
Zhang, Yang
Salmena, Leonardo
Pandolfi, Pier Paolo
Poliseno, Laura
PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title_full PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title_fullStr PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title_full_unstemmed PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title_short PTENP1 is a ceRNA for PTEN: it’s CRISPR clear
title_sort ptenp1 is a cerna for pten: it’s crispr clear
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285706/
https://www.ncbi.nlm.nih.gov/pubmed/32517731
http://dx.doi.org/10.1186/s13045-020-00894-2
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