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Signal transducer and activator of transcription 6 as a target in colon cancer therapy
Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal canc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285805/ https://www.ncbi.nlm.nih.gov/pubmed/32565970 http://dx.doi.org/10.3892/ol.2020.11614 |
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author | Delgado-Ramirez, Yael Colly, Vaneesa Gonzalez, Giovanni Villanueva Leon-Cabrera, Sonia |
author_facet | Delgado-Ramirez, Yael Colly, Vaneesa Gonzalez, Giovanni Villanueva Leon-Cabrera, Sonia |
author_sort | Delgado-Ramirez, Yael |
collection | PubMed |
description | Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduces signals in response to the binding of interleukin (IL)-4 and IL-13 to their receptors and regulates the expression of genes involved in the immune response, cell survival, tumor proliferation and metastasis. Patients with colorectal cancer exhibit high STAT6 activity in the colonic epithelium, and STAT6 expression is associated with lower survival rates, lymph node metastasis, changes in the epithelial barrier function and alterations in the inflammatory response. A number of studies investigating experimental models and cancer cell lines have revealed that STAT6 is associated with tumor growth and development, as well as with increased invasion and metastasis, suggesting that STAT6 inhibition may serve as a novel therapeutic strategy in colon cancer. The present review summarizes the evidence with regard to the implications of STAT6 in cancer biology and the direct and indirect effects on colon tumor transformation. Furthermore, the current treatment strategies targeting the IL-4/IL-13/STAT6 axis in colon cancer are discussed. |
format | Online Article Text |
id | pubmed-7285805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-72858052020-06-18 Signal transducer and activator of transcription 6 as a target in colon cancer therapy Delgado-Ramirez, Yael Colly, Vaneesa Gonzalez, Giovanni Villanueva Leon-Cabrera, Sonia Oncol Lett Review Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of proteins that serve key roles in the initiation of tumorigenesis and malignant transformation. STAT6 is highly expressed in several types of cancer, including breast, pancreatic, prostate and colorectal cancer. STAT6 transduces signals in response to the binding of interleukin (IL)-4 and IL-13 to their receptors and regulates the expression of genes involved in the immune response, cell survival, tumor proliferation and metastasis. Patients with colorectal cancer exhibit high STAT6 activity in the colonic epithelium, and STAT6 expression is associated with lower survival rates, lymph node metastasis, changes in the epithelial barrier function and alterations in the inflammatory response. A number of studies investigating experimental models and cancer cell lines have revealed that STAT6 is associated with tumor growth and development, as well as with increased invasion and metastasis, suggesting that STAT6 inhibition may serve as a novel therapeutic strategy in colon cancer. The present review summarizes the evidence with regard to the implications of STAT6 in cancer biology and the direct and indirect effects on colon tumor transformation. Furthermore, the current treatment strategies targeting the IL-4/IL-13/STAT6 axis in colon cancer are discussed. D.A. Spandidos 2020-07 2020-05-13 /pmc/articles/PMC7285805/ /pubmed/32565970 http://dx.doi.org/10.3892/ol.2020.11614 Text en Copyright: © Delgado-Ramirez et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Delgado-Ramirez, Yael Colly, Vaneesa Gonzalez, Giovanni Villanueva Leon-Cabrera, Sonia Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title | Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title_full | Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title_fullStr | Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title_full_unstemmed | Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title_short | Signal transducer and activator of transcription 6 as a target in colon cancer therapy |
title_sort | signal transducer and activator of transcription 6 as a target in colon cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285805/ https://www.ncbi.nlm.nih.gov/pubmed/32565970 http://dx.doi.org/10.3892/ol.2020.11614 |
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