Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells

Salvianolic acid B (Sal-B) is widely used in China for the treatment of numerous diseases. Currently, Salvia miltiorrhiza Bunge is the main source of this compound, but Salvia bowleyana Dunn, a surrogate of S. miltiorrhiza Bge, may provide a novel source for obtaining more Sal-B. In the present stud...

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Autores principales: Chen, Binghua, Huang, Chaoqun, Zhang, Yuanyan, Tang, Xiaoqiong, Li, Suhuan, Wang, Qingshui, Lin, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285817/
https://www.ncbi.nlm.nih.gov/pubmed/32566009
http://dx.doi.org/10.3892/ol.2020.11611
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author Chen, Binghua
Huang, Chaoqun
Zhang, Yuanyan
Tang, Xiaoqiong
Li, Suhuan
Wang, Qingshui
Lin, Yao
author_facet Chen, Binghua
Huang, Chaoqun
Zhang, Yuanyan
Tang, Xiaoqiong
Li, Suhuan
Wang, Qingshui
Lin, Yao
author_sort Chen, Binghua
collection PubMed
description Salvianolic acid B (Sal-B) is widely used in China for the treatment of numerous diseases. Currently, Salvia miltiorrhiza Bunge is the main source of this compound, but Salvia bowleyana Dunn, a surrogate of S. miltiorrhiza Bge, may provide a novel source for obtaining more Sal-B. In the present study, a simple method for separation and purification of phenolic compounds from S. bowleyana Dunn roots was employed. Sal-B was subsequently purified and its inhibitory effect on the gastric cancer HGC-27 and AGS cell lines was investigated. Sal-B extracted from S. bowleyana Dunn displayed significant antitumor activity in proliferation and apoptosis assays. Overall, it was found that S. bowleyana Dunn has a higher Sal-B content than S. miltiorrhiza Bge and may be used as a novel source of this potential anti-gastric cancer compound.
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spelling pubmed-72858172020-06-18 Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells Chen, Binghua Huang, Chaoqun Zhang, Yuanyan Tang, Xiaoqiong Li, Suhuan Wang, Qingshui Lin, Yao Oncol Lett Articles Salvianolic acid B (Sal-B) is widely used in China for the treatment of numerous diseases. Currently, Salvia miltiorrhiza Bunge is the main source of this compound, but Salvia bowleyana Dunn, a surrogate of S. miltiorrhiza Bge, may provide a novel source for obtaining more Sal-B. In the present study, a simple method for separation and purification of phenolic compounds from S. bowleyana Dunn roots was employed. Sal-B was subsequently purified and its inhibitory effect on the gastric cancer HGC-27 and AGS cell lines was investigated. Sal-B extracted from S. bowleyana Dunn displayed significant antitumor activity in proliferation and apoptosis assays. Overall, it was found that S. bowleyana Dunn has a higher Sal-B content than S. miltiorrhiza Bge and may be used as a novel source of this potential anti-gastric cancer compound. D.A. Spandidos 2020-07 2020-05-13 /pmc/articles/PMC7285817/ /pubmed/32566009 http://dx.doi.org/10.3892/ol.2020.11611 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chen, Binghua
Huang, Chaoqun
Zhang, Yuanyan
Tang, Xiaoqiong
Li, Suhuan
Wang, Qingshui
Lin, Yao
Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title_full Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title_fullStr Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title_full_unstemmed Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title_short Salvia bowleyana Dunn root is a novel source of salvianolic acid B and displays antitumor effects against gastric cancer cells
title_sort salvia bowleyana dunn root is a novel source of salvianolic acid b and displays antitumor effects against gastric cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285817/
https://www.ncbi.nlm.nih.gov/pubmed/32566009
http://dx.doi.org/10.3892/ol.2020.11611
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