Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae)

Four peptides with cytotoxic activity against BRIN-BD11 rat clonal β-cells were purified from the venom of the black-necked spitting cobra Naja nigricollis using reversed-phase HPLC. The peptides were identified as members of the three-finger superfamily of snake toxins by ESI-MS/MS sequencing of tr...

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Detalles Bibliográficos
Autores principales: Conlon, J.M., Attoub, Samir, Musale, Vishal, Leprince, Jérôme, Casewell, Nicholas R., Sanz, Libia, Calvete, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Venomics at the crossroads between ecological and clinical toxinology, Edited by: Dr. Juan Calvete, Dr.Jose Maria Gutiérrez and Dr. Cleópatra A.S. Caldeira
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285909/
https://www.ncbi.nlm.nih.gov/pubmed/32550585
http://dx.doi.org/10.1016/j.toxcx.2020.100030

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