In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

We have investigated the in vitro metabolism of pectenotoxin-2 (PTX-2) using primary hepatocytes from Wistar rats in suspension. Purified PTX-2 was rapidly metabolized. Two major and several minor oxidized PTX-2 metabolites were formed, none of which had retention times corresponding to PTX-1, -11,...

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Detalles Bibliográficos
Autores principales: Sandvik, Morten, Miles, Christopher O., Wilkins, Alistair L., Fæste, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285913/
https://www.ncbi.nlm.nih.gov/pubmed/32550586
http://dx.doi.org/10.1016/j.toxcx.2020.100031

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