Distribution of major toxins in Rhinella marina parotoid macroglands using Desorption-Electrospray-Ionization mass spectrometry imaging (DESI-MSI)

Amphibian cutaneous glands secrete toxins used in different vital functions including passive defense. Through Desorption Electrospray Ionization-Imaging we analyzed the distribution of the major toxins of the toad Rhinella marina parotoid macroglands. Alkaloids and steroids showed characteristic di...

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Detalles Bibliográficos
Autores principales: Mailho-Fontana, Pedro L., Porcari, Andreia M., Eberlin, Marcos N., Jared, Carlos, Antoniazzi, Marta Maria, Pimenta, Daniel C., Sciani, Juliana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Venomics at the crossroads between ecological and clinical toxinology, Edited by: Dr. Juan Calvete, Dr.Jose Maria Gutiérrez and Dr. Cleópatra A.S. Caldeira
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286094/
https://www.ncbi.nlm.nih.gov/pubmed/32550588
http://dx.doi.org/10.1016/j.toxcx.2020.100033
Descripción
Sumario:Amphibian cutaneous glands secrete toxins used in different vital functions including passive defense. Through Desorption Electrospray Ionization-Imaging we analyzed the distribution of the major toxins of the toad Rhinella marina parotoid macroglands. Alkaloids and steroids showed characteristic distribution and intensity within the glands and were also present at lower levels on the skin surface. A comprehensive overview of toxins distribution in toads’ skin might help to understand their full biological role within the amphibians.

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