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CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE
For clinical studies of sarcopenia and frailty, clinically meaningful outcome measures are needed to monitor disease progression, evaluate efficacy of interventions, and plan clinical trials. Physical performance measures including measures of gait speed and other aspects of mobility and strength ha...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286121/ https://www.ncbi.nlm.nih.gov/pubmed/32150208 http://dx.doi.org/10.14283/jfa.2019.33 |
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author | GURALNIK, J. BANDEEN-ROCHE, K. BHASIN, S.A.R. EREMENCO, S. LANDI, F. MUSCEDERE, J. PERERA, S. REGINSTER, J.-Y. WOODHOUSE, L. VELLAS, B. |
author_facet | GURALNIK, J. BANDEEN-ROCHE, K. BHASIN, S.A.R. EREMENCO, S. LANDI, F. MUSCEDERE, J. PERERA, S. REGINSTER, J.-Y. WOODHOUSE, L. VELLAS, B. |
author_sort | GURALNIK, J. |
collection | PubMed |
description | For clinical studies of sarcopenia and frailty, clinically meaningful outcome measures are needed to monitor disease progression, evaluate efficacy of interventions, and plan clinical trials. Physical performance measures including measures of gait speed and other aspects of mobility and strength have been used in many studies, although a definition of clinically meaningful change in performance has remained unclear. The International Conference on Frailty and Sarcopenia Research Task Force (ICFSR-TF), a group of academic and industry scientists investigating frailty and sarcopenia, met in Miami Beach, Florida, USA in February 2019 to explore approaches for establishing clinical meaningfulness in a manner aligned with regulatory authorities. They concluded that clinical meaningful change is contextually dependent, and that both anchor-based and distribution-based methods of quantifying physical function are informative and should be evaluated relative to patient-reported outcomes. In addition, they identified additional research needed to enable setting criteria for clinical meaningful change in trials. |
format | Online Article Text |
id | pubmed-7286121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-72861212020-06-10 CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE GURALNIK, J. BANDEEN-ROCHE, K. BHASIN, S.A.R. EREMENCO, S. LANDI, F. MUSCEDERE, J. PERERA, S. REGINSTER, J.-Y. WOODHOUSE, L. VELLAS, B. J Frailty Aging Article For clinical studies of sarcopenia and frailty, clinically meaningful outcome measures are needed to monitor disease progression, evaluate efficacy of interventions, and plan clinical trials. Physical performance measures including measures of gait speed and other aspects of mobility and strength have been used in many studies, although a definition of clinically meaningful change in performance has remained unclear. The International Conference on Frailty and Sarcopenia Research Task Force (ICFSR-TF), a group of academic and industry scientists investigating frailty and sarcopenia, met in Miami Beach, Florida, USA in February 2019 to explore approaches for establishing clinical meaningfulness in a manner aligned with regulatory authorities. They concluded that clinical meaningful change is contextually dependent, and that both anchor-based and distribution-based methods of quantifying physical function are informative and should be evaluated relative to patient-reported outcomes. In addition, they identified additional research needed to enable setting criteria for clinical meaningful change in trials. 2020 /pmc/articles/PMC7286121/ /pubmed/32150208 http://dx.doi.org/10.14283/jfa.2019.33 Text en This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. |
spellingShingle | Article GURALNIK, J. BANDEEN-ROCHE, K. BHASIN, S.A.R. EREMENCO, S. LANDI, F. MUSCEDERE, J. PERERA, S. REGINSTER, J.-Y. WOODHOUSE, L. VELLAS, B. CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title | CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title_full | CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title_fullStr | CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title_full_unstemmed | CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title_short | CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE |
title_sort | clinically meaningful change for physical performance: perspectives of the icfsr task force |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286121/ https://www.ncbi.nlm.nih.gov/pubmed/32150208 http://dx.doi.org/10.14283/jfa.2019.33 |
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