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The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer

INTRODUCTION: Lung cancer is the leading cause of cancer-associated mortality worldwide. Recently, long non-coding RNAs (lncRNAs) have been studied as key regulators in some biological processes. Of note, the molecular mechanism and prognostic value of lncRNAs in non-small cell lung cancer (NSCLC) h...

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Autores principales: Huang, Hai-Tao, Xu, Yi-Ming, Ding, Sheng-Guang, Yu, Xiao-Qiang, Wang, Fei, Wang, Hai-Feng, Tian, Xue, Zhong, Chong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286322/
https://www.ncbi.nlm.nih.gov/pubmed/32542097
http://dx.doi.org/10.5114/aoms.2020.93535
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author Huang, Hai-Tao
Xu, Yi-Ming
Ding, Sheng-Guang
Yu, Xiao-Qiang
Wang, Fei
Wang, Hai-Feng
Tian, Xue
Zhong, Chong-Jun
author_facet Huang, Hai-Tao
Xu, Yi-Ming
Ding, Sheng-Guang
Yu, Xiao-Qiang
Wang, Fei
Wang, Hai-Feng
Tian, Xue
Zhong, Chong-Jun
author_sort Huang, Hai-Tao
collection PubMed
description INTRODUCTION: Lung cancer is the leading cause of cancer-associated mortality worldwide. Recently, long non-coding RNAs (lncRNAs) have been studied as key regulators in some biological processes. Of note, the molecular mechanism and prognostic value of lncRNAs in non-small cell lung cancer (NSCLC) have largely remained unclear. MATERIAL AND METHODS: In this study, we compared the PTTG3P expression levels between lung cancer and normal lung samples by analyzing 5 public datasets (GSE18842, GSE19804, GSE27262, GSE30219, and GSE19188). Next, pentose phosphate pathway and co-expression networks were constructed to identify key targets of lncRNA PTTG3P. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore the potential roles of lncRNA PTTG3P. Moreover, we constructed PTTG3P-mediated ceRNA networks in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). RESULTS: In the present study, our analysis showed that PTTG3P expression was higher in high T stage LUAD and LUSC samples, as well as high N stage NSCLC tissues. Of note, we found that higher PTTG3P expression is correlated with shorter survival time in NSCLC patients by analyzing Kaplan-Meier plotter datasets. We found that PTTG3P was significantly associated with NSCLC cell proliferation regulation by affecting a series of cell cycle related biological processes. CONCLUSIONS: Bioinformatics analysis showed that PTTG3P was associated with NSCLC cell proliferation. These results suggested that PTTG3P could serve as a new therapeutic and prognostic target for NSCLC.
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spelling pubmed-72863222020-06-14 The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer Huang, Hai-Tao Xu, Yi-Ming Ding, Sheng-Guang Yu, Xiao-Qiang Wang, Fei Wang, Hai-Feng Tian, Xue Zhong, Chong-Jun Arch Med Sci Basic Research INTRODUCTION: Lung cancer is the leading cause of cancer-associated mortality worldwide. Recently, long non-coding RNAs (lncRNAs) have been studied as key regulators in some biological processes. Of note, the molecular mechanism and prognostic value of lncRNAs in non-small cell lung cancer (NSCLC) have largely remained unclear. MATERIAL AND METHODS: In this study, we compared the PTTG3P expression levels between lung cancer and normal lung samples by analyzing 5 public datasets (GSE18842, GSE19804, GSE27262, GSE30219, and GSE19188). Next, pentose phosphate pathway and co-expression networks were constructed to identify key targets of lncRNA PTTG3P. Furthermore, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to explore the potential roles of lncRNA PTTG3P. Moreover, we constructed PTTG3P-mediated ceRNA networks in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). RESULTS: In the present study, our analysis showed that PTTG3P expression was higher in high T stage LUAD and LUSC samples, as well as high N stage NSCLC tissues. Of note, we found that higher PTTG3P expression is correlated with shorter survival time in NSCLC patients by analyzing Kaplan-Meier plotter datasets. We found that PTTG3P was significantly associated with NSCLC cell proliferation regulation by affecting a series of cell cycle related biological processes. CONCLUSIONS: Bioinformatics analysis showed that PTTG3P was associated with NSCLC cell proliferation. These results suggested that PTTG3P could serve as a new therapeutic and prognostic target for NSCLC. Termedia Publishing House 2020-03-09 /pmc/articles/PMC7286322/ /pubmed/32542097 http://dx.doi.org/10.5114/aoms.2020.93535 Text en Copyright © 2020 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Basic Research
Huang, Hai-Tao
Xu, Yi-Ming
Ding, Sheng-Guang
Yu, Xiao-Qiang
Wang, Fei
Wang, Hai-Feng
Tian, Xue
Zhong, Chong-Jun
The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title_full The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title_fullStr The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title_full_unstemmed The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title_short The novel lncRNA PTTG3P is downregulated and predicts poor prognosis in non-small cell lung cancer
title_sort novel lncrna pttg3p is downregulated and predicts poor prognosis in non-small cell lung cancer
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286322/
https://www.ncbi.nlm.nih.gov/pubmed/32542097
http://dx.doi.org/10.5114/aoms.2020.93535
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