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Polarized epidermal growth factor secretion ensures robust vulval cell fate specification in Caenorhabditis elegans

The anchor cell (AC) in C. elegans secretes an epidermal growth factor (EGF) homolog that induces adjacent vulval precursor cells (VPCs) to differentiate. The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we...

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Detalles Bibliográficos
Autores principales:	Mereu, Louisa, Morf, Matthias K., Spiri, Silvan, Gutierrez, Peter, Escobar-Restrepo, Juan M., Daube, Michael, Walser, Michael, Hajnal, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286359/ https://www.ncbi.nlm.nih.gov/pubmed/32439759 http://dx.doi.org/10.1242/dev.175760

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