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Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution
Comparative genomic approaches have been used to identify sites where mutations are under purifying selection and of functional consequence by searching for sequences that are conserved across distantly related species. However, the performance of these approaches has not been rigorously evaluated u...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286533/ https://www.ncbi.nlm.nih.gov/pubmed/32469868 http://dx.doi.org/10.1371/journal.pgen.1008827 |