Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update

As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of dru...

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Detalles Bibliográficos
Autores principales: Pal, Amit, Pawar, Anil, Goswami, Kalyan, Sharma, Praveen, Prasad, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286553/
https://www.ncbi.nlm.nih.gov/pubmed/32641874
http://dx.doi.org/10.1007/s12291-020-00900-x
Descripción
Sumario:As the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug “Hydroxychloroquine” as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12291-020-00900-x) contains supplementary material, which is available to authorized users.

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