Clinical and Radiological Features of Patients With Pulmonary Cryptococcosis in a Hospital of North China

Objective: The increasing incidence has led to more focus on pulmonary cryptococcosis in HIV-negative patients. We conducted a retrospective analysis of pulmonary cryptococcosis to understand the clinical characteristics, imaging features, diagnosis, treatment and prognosis of this disease in HIV-negative patients in respiratory department of a tertiary hospital in north China. Method: We identified retrospectively those diagnosed with pulmonary cryptococcosis in the first medical center of Chinese People’s Liberation Army General Hospital since 2009 to 2019. The clinical and image data were collected and analyzed. Results: The study involved 34 patients with pulmonary cryptococcosis. All patients were diagnosed by histopathology. It accounted for 0.93‰ of the total number of patients admitted to respiratory department in the same period. The mean age was 49 years; 26 patients (76.5%) were male. Patients were predominantly immunocompetent (30, 88.2%), and there was no underlying disease for most patients (26, 76.5%). The most frequent symptoms were cough and expectoration. Fourteen (41.2%) patients showed no symptom or sign. Multiple lesions (21, 61.8%) and subpleural lesions (23, 67.6%) were the most common. Nodule was the most common abnormality on chest computed tomography image. Eight (23.5%) patients received serum Cryptococcus capsular polysaccharide antigen test, and seven patients showed positive result. All patients recovered after antifungal treatment. Conclusions: Most patients of HIV-negative pulmonary cryptococcosis were mainly immunocompetent patients younger than 60 years without underlying diseases. There was lack of specificity in clinical manifestations and imaging findings. The prognosis of pulmonary cryptococcosis in HIV-negative patients was good.