The emerging roles of WBP2 oncogene in human cancers

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research...

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Detalles Bibliográficos
Autores principales: Tabatabaeian, Hossein, Rao, Angad, Ramos, Alisha, Chu, Tinghine, Sudol, Marius, Lim, Yoon Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286818/
https://www.ncbi.nlm.nih.gov/pubmed/32393834
http://dx.doi.org/10.1038/s41388-020-1318-0
Descripción
Sumario:WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

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