The emerging roles of WBP2 oncogene in human cancers

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research...

Descripción completa

Detalles Bibliográficos
Autores principales: Tabatabaeian, Hossein, Rao, Angad, Ramos, Alisha, Chu, Tinghine, Sudol, Marius, Lim, Yoon Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286818/
https://www.ncbi.nlm.nih.gov/pubmed/32393834
http://dx.doi.org/10.1038/s41388-020-1318-0
_version_ 1783544934667649024
author Tabatabaeian, Hossein
Rao, Angad
Ramos, Alisha
Chu, Tinghine
Sudol, Marius
Lim, Yoon Pin
author_facet Tabatabaeian, Hossein
Rao, Angad
Ramos, Alisha
Chu, Tinghine
Sudol, Marius
Lim, Yoon Pin
author_sort Tabatabaeian, Hossein
collection PubMed
description WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.
format Online
Article
Text
id pubmed-7286818
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-72868182020-06-15 The emerging roles of WBP2 oncogene in human cancers Tabatabaeian, Hossein Rao, Angad Ramos, Alisha Chu, Tinghine Sudol, Marius Lim, Yoon Pin Oncogene Review Article WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PI(3)K, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine. Nature Publishing Group UK 2020-05-11 2020 /pmc/articles/PMC7286818/ /pubmed/32393834 http://dx.doi.org/10.1038/s41388-020-1318-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Tabatabaeian, Hossein
Rao, Angad
Ramos, Alisha
Chu, Tinghine
Sudol, Marius
Lim, Yoon Pin
The emerging roles of WBP2 oncogene in human cancers
title The emerging roles of WBP2 oncogene in human cancers
title_full The emerging roles of WBP2 oncogene in human cancers
title_fullStr The emerging roles of WBP2 oncogene in human cancers
title_full_unstemmed The emerging roles of WBP2 oncogene in human cancers
title_short The emerging roles of WBP2 oncogene in human cancers
title_sort emerging roles of wbp2 oncogene in human cancers
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286818/
https://www.ncbi.nlm.nih.gov/pubmed/32393834
http://dx.doi.org/10.1038/s41388-020-1318-0
work_keys_str_mv AT tabatabaeianhossein theemergingrolesofwbp2oncogeneinhumancancers
AT raoangad theemergingrolesofwbp2oncogeneinhumancancers
AT ramosalisha theemergingrolesofwbp2oncogeneinhumancancers
AT chutinghine theemergingrolesofwbp2oncogeneinhumancancers
AT sudolmarius theemergingrolesofwbp2oncogeneinhumancancers
AT limyoonpin theemergingrolesofwbp2oncogeneinhumancancers
AT tabatabaeianhossein emergingrolesofwbp2oncogeneinhumancancers
AT raoangad emergingrolesofwbp2oncogeneinhumancancers
AT ramosalisha emergingrolesofwbp2oncogeneinhumancancers
AT chutinghine emergingrolesofwbp2oncogeneinhumancancers
AT sudolmarius emergingrolesofwbp2oncogeneinhumancancers
AT limyoonpin emergingrolesofwbp2oncogeneinhumancancers

Ejemplares similares