Inhibition of the prostaglandin D(2)–GPR44/DP2 axis improves human islet survival and function

AIMS/HYPOTHESIS: Inflammatory signals and increased prostaglandin synthesis play a role during the development of diabetes. The prostaglandin D(2) (PGD(2)) receptor, GPR44/DP2, is highly expressed in human islets and activation of the pathway results in impaired insulin secretion. The role of GPR44...

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Detalles Bibliográficos
Autores principales: Abadpour, Shadab, Tyrberg, Björn, Schive, Simen W., Huldt, Charlotte Wennberg, Gennemark, Peter, Ryberg, Erik, Rydén-Bergsten, Tina, Smith, David M., Korsgren, Olle, Skrtic, Stanko, Scholz, Hanne, Winzell, Maria Sörhede
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286861/
https://www.ncbi.nlm.nih.gov/pubmed/32350565
http://dx.doi.org/10.1007/s00125-020-05138-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286861/
https://www.ncbi.nlm.nih.gov/pubmed/32350565
http://dx.doi.org/10.1007/s00125-020-05138-z

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