Aldehyde-alcohol dehydrogenase undergoes structural transition to form extended spirosomes for substrate channeling

Aldehyde-alcohol dehydrogenase (AdhE) is an enzyme responsible for converting acetyl-CoA to ethanol via acetaldehyde using NADH. AdhE is composed of two catalytic domains of aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH), and forms a spirosome architecture critical for AdhE activity....

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Detalles Bibliográficos
Autores principales: Kim, Gijeong, Yang, Jinsol, Jang, Juwon, Choi, Jin-Seok, Roe, Andrew J., Byron, Olwyn, Seok, Chaok, Song, Ji-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286902/
https://www.ncbi.nlm.nih.gov/pubmed/32523125
http://dx.doi.org/10.1038/s42003-020-1030-1

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