Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease

Dominant and recessive mutations in podocalyxin (PODXL) are associated with human kidney disease. Interestingly, some PODXL mutations manifest as anuria while others are associated with proteinuric kidney disease. PODXL heterozygosity is associated with adult-onset kidney disease and podocalyxin she...

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Detalles Bibliográficos
Autores principales: Refaeli, Ido, Hughes, Michael R., Wong, Alvin Ka-Wai, Bissonnette, Mei Lin Z., Roskelley, Calvin D., Wayne Vogl, A., Barbour, Sean J., Freedman, Benjamin S., McNagny, Kelly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286918/
https://www.ncbi.nlm.nih.gov/pubmed/32523052
http://dx.doi.org/10.1038/s41598-020-64907-3

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