Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a geneti...

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Autores principales: Knights, Alexander J., Vohralik, Emily J., Houweling, Peter J., Stout, Elizabeth S., Norton, Laura J., Alexopoulos, Stephanie J., Yik, Jinfen. J., Mat Jusoh, Hanapi, Olzomer, Ellen M., Bell-Anderson, Kim S., North, Kathryn N., Hoehn, Kyle L., Crossley, Merlin, Quinlan, Kate G. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286919/
https://www.ncbi.nlm.nih.gov/pubmed/32523103
http://dx.doi.org/10.1038/s41467-020-16758-9
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author Knights, Alexander J.
Vohralik, Emily J.
Houweling, Peter J.
Stout, Elizabeth S.
Norton, Laura J.
Alexopoulos, Stephanie J.
Yik, Jinfen. J.
Mat Jusoh, Hanapi
Olzomer, Ellen M.
Bell-Anderson, Kim S.
North, Kathryn N.
Hoehn, Kyle L.
Crossley, Merlin
Quinlan, Kate G. R.
author_facet Knights, Alexander J.
Vohralik, Emily J.
Houweling, Peter J.
Stout, Elizabeth S.
Norton, Laura J.
Alexopoulos, Stephanie J.
Yik, Jinfen. J.
Mat Jusoh, Hanapi
Olzomer, Ellen M.
Bell-Anderson, Kim S.
North, Kathryn N.
Hoehn, Kyle L.
Crossley, Merlin
Quinlan, Kate G. R.
author_sort Knights, Alexander J.
collection PubMed
description The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis.
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spelling pubmed-72869192020-06-16 Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3) Knights, Alexander J. Vohralik, Emily J. Houweling, Peter J. Stout, Elizabeth S. Norton, Laura J. Alexopoulos, Stephanie J. Yik, Jinfen. J. Mat Jusoh, Hanapi Olzomer, Ellen M. Bell-Anderson, Kim S. North, Kathryn N. Hoehn, Kyle L. Crossley, Merlin Quinlan, Kate G. R. Nat Commun Article The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis. Nature Publishing Group UK 2020-06-10 /pmc/articles/PMC7286919/ /pubmed/32523103 http://dx.doi.org/10.1038/s41467-020-16758-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Knights, Alexander J.
Vohralik, Emily J.
Houweling, Peter J.
Stout, Elizabeth S.
Norton, Laura J.
Alexopoulos, Stephanie J.
Yik, Jinfen. J.
Mat Jusoh, Hanapi
Olzomer, Ellen M.
Bell-Anderson, Kim S.
North, Kathryn N.
Hoehn, Kyle L.
Crossley, Merlin
Quinlan, Kate G. R.
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title_full Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title_fullStr Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title_full_unstemmed Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title_short Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
title_sort eosinophil function in adipose tissue is regulated by krüppel-like factor 3 (klf3)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286919/
https://www.ncbi.nlm.nih.gov/pubmed/32523103
http://dx.doi.org/10.1038/s41467-020-16758-9
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