A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an approach to uncover the efficacy of drug combinations based on the analysis of mono-drug effects. For this we used dose-response data from pharma...

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Detalles Bibliográficos
Autores principales: Narayan, Ravi S., Molenaar, Piet, Teng, Jian, Cornelissen, Fleur M. G., Roelofs, Irene, Menezes, Renee, Dik, Rogier, Lagerweij, Tonny, Broersma, Yoran, Petersen, Naomi, Marin Soto, Jhon Alexander, Brands, Eelke, van Kuiken, Philip, Lecca, Maria C., Lenos, Kristiaan J., In ‘t Veld, Sjors G. J. G., van Wieringen, Wessel, Lang, Frederick F., Sulman, Erik, Verhaak, Roel, Baumert, Brigitta G., Stalpers, Lucas J. A., Vermeulen, Louis, Watts, Colin, Bailey, David, Slotman, Ben J., Versteeg, Rogier, Noske, David, Sminia, Peter, Tannous, Bakhos A., Wurdinger, Tom, Koster, Jan, Westerman, Bart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287046/
https://www.ncbi.nlm.nih.gov/pubmed/32523045
http://dx.doi.org/10.1038/s41467-020-16735-2

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