LRRK2-Related Parkinson’s Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis

Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are associated with both familial and sporadic Parkinson’s disease (PD). LRRK2 encodes a large protein comprised of a GTPase and a kinase domain. All pathogenic variants converge on enhancing LRRK2 kinase substrate phosphorylati...

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Detalles Bibliográficos
Autores principales: Rivero-Ríos, Pilar, Romo-Lozano, María, Fasiczka, Rachel, Naaldijk, Yahaira, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287096/
https://www.ncbi.nlm.nih.gov/pubmed/32581693
http://dx.doi.org/10.3389/fnins.2020.00556

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