Cargando…

Clinical Validation of Targeted and Untargeted Metabolomics Testing for Genetic Disorders: A 3 Year Comparative Study

Global untargeted metabolomics (GUM) has entered clinical diagnostics for genetic disorders. We compared the clinical utility of GUM with traditional targeted metabolomics (TM) as a screening tool in patients with established genetic disorders and determined the scope of GUM as a discovery tool in p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Almontashiri, Naif A. M., Zha, Li, Young, Kim, Law, Terence, Kellogg, Mark D., Bodamer, Olaf A., Peake, Roy W. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287104/ https://www.ncbi.nlm.nih.gov/pubmed/32523032 http://dx.doi.org/10.1038/s41598-020-66401-2

Ejemplares similares

Author Correction: Clinical Validation of Targeted and Untargeted Metabolomics Testing for Genetic Disorders: A 3 Year Comparative Study
por: Almontashiri, Naif A. M., et al.
Publicado: (2020)

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics
por: Crone, William J. K., et al.
Publicado: (2016)

A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics
por: Bliziotis, Nikolaos G., et al.
Publicado: (2020)

Variable Selection in Untargeted Metabolomics and the Danger of Sparsity
por: Tinnevelt, Gerjen H., et al.
Publicado: (2020)

The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism
por: Almontashiri, Naif A.M.
Publicado: (2017)

Evaluation of the use of untargeted metabolomics in the safety assessment of genetically modified crops
por: Bedair, Mohamed, et al.
Publicado: (2020)

Comparative Untargeted Metabolomic Profiling of Induced Mitochondrial Fusion in Pancreatic Cancer
por: Nguyen, Nicholas D., et al.
Publicado: (2021)

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome
por: Hsu, Yu-Han H., et al.
Publicado: (2020)

Untargeted Metabolomics for Autism Spectrum Disorders: Current Status and Future Directions
por: Glinton, Kevin E., et al.
Publicado: (2019)

Untargeted metabolomic analysis of metabolites related to body dysmorphic disorder (BDD)
por: Wang, Yawen, et al.
Publicado: (2023)

Untargeted Metabolomic Characterization of Ovarian Tumors
por: Liu, Xiaona, et al.
Publicado: (2020)

Editorial: Advances and challenges in untargeted metabolomics
por: Wawrzyniak, Renata, et al.
Publicado: (2023)

Targeted and untargeted metabolomic approach for GDM diagnosis
por: Burzynska-Pedziwiatr, Izabela, et al.
Publicado: (2023)

Untargeted metabolomics analysis in drug-naïve patients with severe obsessive–compulsive disorder
por: Li, Zheqin, et al.
Publicado: (2023)

Untargeted metabolomics yields insight into ALS disease mechanisms
por: Goutman, Stephen A, et al.
Publicado: (2020)

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
por: Vincent, Isabel M., et al.
Publicado: (2016)

Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics
por: Martín-Blázquez, Ariadna, et al.
Publicado: (2020)

Current Practice in Untargeted Human Milk Metabolomics
por: Ten-Doménech, Isabel, et al.
Publicado: (2020)

An Untargeted Metabolomics Approach on Carfilzomib-Induced Nephrotoxicity
por: Barla, Ioanna, et al.
Publicado: (2022)

Progressive Ataxia and Neurologic Regression in RFXANK-Associated Bare Lymphocyte Syndrome
por: Alharby, Essa, et al.
Publicado: (2021)

Improved batch correction in untargeted MS-based metabolomics
por: Wehrens, Ron, et al.
Publicado: (2016)

Untargeted analysis of the serum metabolome in cats with exocrine pancreatic insufficiency
por: Barko, Patrick C., et al.
Publicado: (2021)

Untargeted Analysis of Serum Metabolomes in Dogs with Exocrine Pancreatic Insufficiency
por: Barko, Patrick C., et al.
Publicado: (2023)

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild Ophiocordyceps sinensis
por: Zhou, Jinna, et al.
Publicado: (2022)

Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women
por: Bosman, Pauline, et al.
Publicado: (2022)

The Thing Metabolome Repository family (XMRs): comparable untargeted metabolome databases for analyzing sample-specific unknown metabolites
por: Sakurai, Nozomu, et al.
Publicado: (2022)

Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection
por: Nunes, Estéfane da C., et al.
Publicado: (2021)

Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus)
por: Malheiros, Jessica Moraes, et al.
Publicado: (2021)

Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism
por: Miller, Marcus J., et al.
Publicado: (2015)

Untargeted metabolomics links glutathione to bacterial cell cycle progression
por: Hartl, Johannes, et al.
Publicado: (2020)

Unravelling Plant Responses to Stress—The Importance of Targeted and Untargeted Metabolomics
por: Allwood, James William, et al.
Publicado: (2021)

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways
por: Cho, Kyuil, et al.
Publicado: (2014)

Analytical Methods in Untargeted Metabolomics: State of the Art in 2015
por: Alonso, Arnald, et al.
Publicado: (2015)

Filtering procedures for untargeted LC-MS metabolomics data
por: Schiffman, Courtney, et al.
Publicado: (2019)

Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics
por: Ismail, Israa T, et al.
Publicado: (2019)

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits
por: Lim, Vuanghao, et al.
Publicado: (2020)

Untargeted metabolomics approach to discriminate mistletoe commercial products
por: Vanhaverbeke, Cécile, et al.
Publicado: (2021)

Investigation of pathogenesis of hyperuricemia based on untargeted and targeted metabolomics
por: Qin, Nankun, et al.
Publicado: (2022)

Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction
por: Cao, Yan, et al.
Publicado: (2023)

Simulated-to-real benchmarking of acquisition methods in untargeted metabolomics
por: Wandy, Joe, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nep0pj1fi4r90fdvb5nnb0ihei