Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism

Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia and autism spectrum disorder (ASD). VIPR2 gene encodes the VPAC2 receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP)....

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Detalles Bibliográficos
Autores principales: Takeuchi, Shuto, Kawanai, Takuya, Yamauchi, Ryosuke, Chen, Lu, Miyaoka, Tatsunori, Yamada, Mei, Asano, Satoshi, Hayata-Takano, Atsuko, Nakazawa, Takanobu, Yano, Koji, Horiguchi, Naotaka, Nakagawa, Shinsaku, Takuma, Kazuhiro, Waschek, James A., Hashimoto, Hitoshi, Ago, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287155/
https://www.ncbi.nlm.nih.gov/pubmed/32581681
http://dx.doi.org/10.3389/fnins.2020.00521

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