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SMARCA4-deficient uterine sarcoma: A case report and a concise review

BACKGROUND: SMARCA4-deficient uterine sarcoma (SDUS) is a newly discovered undifferentiated uterine mesenchymal malignancy which has loss of expression of SMARCA4. CASE: A 46-year-old woman presented with heavy irregular vaginal bleeding over the previous 5 months. Computed tomography and magnetic r...

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Autores principales: Kord, Ali, Eppurath, Atul, Drammeh, Hamidou, Elbaz Younes, Ismail, Xie, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287265/
https://www.ncbi.nlm.nih.gov/pubmed/32551237
http://dx.doi.org/10.1016/j.crwh.2020.e00231
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author Kord, Ali
Eppurath, Atul
Drammeh, Hamidou
Elbaz Younes, Ismail
Xie, Karen L.
author_facet Kord, Ali
Eppurath, Atul
Drammeh, Hamidou
Elbaz Younes, Ismail
Xie, Karen L.
author_sort Kord, Ali
collection PubMed
description BACKGROUND: SMARCA4-deficient uterine sarcoma (SDUS) is a newly discovered undifferentiated uterine mesenchymal malignancy which has loss of expression of SMARCA4. CASE: A 46-year-old woman presented with heavy irregular vaginal bleeding over the previous 5 months. Computed tomography and magnetic resonance imaging showed a large pelvic mass centered within the uterus, suspicious of malignancy with regional metastatic lymphadenopathy. Biopsy confirmed SDUS and patient underwent chemotherapy. Her symptoms improved 3 months after treatment. CONCLUSION: An extremely rare case of this newly described entity is reported. Recognizing the characteristic imaging and pathology findings of SDUS is essential for an accurate diagnosis, which may affect patient survival.
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spelling pubmed-72872652020-06-17 SMARCA4-deficient uterine sarcoma: A case report and a concise review Kord, Ali Eppurath, Atul Drammeh, Hamidou Elbaz Younes, Ismail Xie, Karen L. Case Rep Womens Health Article BACKGROUND: SMARCA4-deficient uterine sarcoma (SDUS) is a newly discovered undifferentiated uterine mesenchymal malignancy which has loss of expression of SMARCA4. CASE: A 46-year-old woman presented with heavy irregular vaginal bleeding over the previous 5 months. Computed tomography and magnetic resonance imaging showed a large pelvic mass centered within the uterus, suspicious of malignancy with regional metastatic lymphadenopathy. Biopsy confirmed SDUS and patient underwent chemotherapy. Her symptoms improved 3 months after treatment. CONCLUSION: An extremely rare case of this newly described entity is reported. Recognizing the characteristic imaging and pathology findings of SDUS is essential for an accurate diagnosis, which may affect patient survival. Elsevier 2020-06-03 /pmc/articles/PMC7287265/ /pubmed/32551237 http://dx.doi.org/10.1016/j.crwh.2020.e00231 Text en © 2020 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kord, Ali
Eppurath, Atul
Drammeh, Hamidou
Elbaz Younes, Ismail
Xie, Karen L.
SMARCA4-deficient uterine sarcoma: A case report and a concise review
title SMARCA4-deficient uterine sarcoma: A case report and a concise review
title_full SMARCA4-deficient uterine sarcoma: A case report and a concise review
title_fullStr SMARCA4-deficient uterine sarcoma: A case report and a concise review
title_full_unstemmed SMARCA4-deficient uterine sarcoma: A case report and a concise review
title_short SMARCA4-deficient uterine sarcoma: A case report and a concise review
title_sort smarca4-deficient uterine sarcoma: a case report and a concise review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287265/
https://www.ncbi.nlm.nih.gov/pubmed/32551237
http://dx.doi.org/10.1016/j.crwh.2020.e00231
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