Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles

A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di-tert-butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substanc...

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Detalles Bibliográficos
Autores principales: Koshelev, Vladimir N., Primerova, Olga V., Vorobyev, Stepan V., Ivanova, Ludmila V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287627/
https://www.ncbi.nlm.nih.gov/pubmed/32443779
http://dx.doi.org/10.3390/molecules25102370
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author Koshelev, Vladimir N.
Primerova, Olga V.
Vorobyev, Stepan V.
Ivanova, Ludmila V.
author_facet Koshelev, Vladimir N.
Primerova, Olga V.
Vorobyev, Stepan V.
Ivanova, Ludmila V.
author_sort Koshelev, Vladimir N.
collection PubMed
description A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di-tert-butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substances were comparable to those of BHT. The obtained compounds were tested for their antibacterial activity, and N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxoethyl)isatin (32 μg/mL) exerted good activity against Staphylococcus aureus.
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spelling pubmed-72876272020-06-15 Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles Koshelev, Vladimir N. Primerova, Olga V. Vorobyev, Stepan V. Ivanova, Ludmila V. Molecules Article A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di-tert-butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substances were comparable to those of BHT. The obtained compounds were tested for their antibacterial activity, and N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxoethyl)isatin (32 μg/mL) exerted good activity against Staphylococcus aureus. MDPI 2020-05-20 /pmc/articles/PMC7287627/ /pubmed/32443779 http://dx.doi.org/10.3390/molecules25102370 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koshelev, Vladimir N.
Primerova, Olga V.
Vorobyev, Stepan V.
Ivanova, Ludmila V.
Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title_full Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title_fullStr Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title_full_unstemmed Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title_short Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
title_sort synthesis, redox properties and antibacterial activity of hindered phenols linked to heterocycles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287627/
https://www.ncbi.nlm.nih.gov/pubmed/32443779
http://dx.doi.org/10.3390/molecules25102370
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