Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

Hypoxia, a common feature of solid tumours’ microenvironment, is associated with an aggressive phenotype and is known to cause resistance to anticancer chemo- and radiotherapies. Tumour-associated carbonic anhydrases isoform IX (hCA IX), which is upregulated under hypoxia in many malignancies partic...

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Detalles Bibliográficos
Autores principales: Anduran, Emilie, Aspatwar, Ashok, Parvathaneni, Nanda-Kumar, Suylen, Dennis, Bua, Silvia, Nocentini, Alessio, Parkkila, Seppo, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Winum, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287649/
https://www.ncbi.nlm.nih.gov/pubmed/32443462
http://dx.doi.org/10.3390/molecules25102347

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