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Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer

Purpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing ho...

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Autores principales: Choi, Se Young, Chi, Byung Hoon, Lee, Wonchul, Lim, Bumjin, You, Dalsan, Kim, Choung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287653/
https://www.ncbi.nlm.nih.gov/pubmed/32365474
http://dx.doi.org/10.3390/jcm9051281
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author Choi, Se Young
Chi, Byung Hoon
Lee, Wonchul
Lim, Bumjin
You, Dalsan
Kim, Choung-Soo
author_facet Choi, Se Young
Chi, Byung Hoon
Lee, Wonchul
Lim, Bumjin
You, Dalsan
Kim, Choung-Soo
author_sort Choi, Se Young
collection PubMed
description Purpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), were measured in 415 patients diagnosed with prostate cancer. Differences in serum hormone concentrations after receiving androgen deprivation therapy (ADT) and after withdrawal from ADT were evaluated. Pathologic characteristics were assessed in the 225 patients unexposed to ADT with a history of radical prostatectomy. Logistic regression analysis was performed to identify factors predictive of unfavorable pathology (Grade ≥3, ≥T3a, or N1). Results: Of the 415 prostate cancer patients, 130 (31.3%) were assessed before treatment, 171 (41.2%) after surgery, 35 (8.4%) after biochemical recurrence, and 59 (14.2%) during ADT, whereas 20 (4.8%) had castration-resistant prostate cancer. FSH was significantly lower after compared to before prostatectomy (3.229 ± 4.486 vs. 5.941 ± 7.044 mIU/mL, p < 0.001). LH, FSH, and testosterone decreased significantly 3 months after starting ADT, but increased 3 months after ADT withdrawal, whereas SHBG was unchanged. Multivariate analysis showed that high LH (odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.03–2.47, p = 0.0376) and prostate-specific antigen (PSA) (OR: 1.13, 95% CI: 1.03–1.24, p = 0.0133) concentrations were significantly associated with a high risk of unfavorable pathology. Conclusions: Sex hormones, including LH, FSH, and testosterone, were affected by ADT. The FSH level decreased after radical prostatectomy. High baseline LH concentration in patients unexposed to ADT was associated with an unfavorable pathology.
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spelling pubmed-72876532020-06-15 Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer Choi, Se Young Chi, Byung Hoon Lee, Wonchul Lim, Bumjin You, Dalsan Kim, Choung-Soo J Clin Med Article Purpose: This study analyzed the association between sex hormone concentrations and stage/condition in patients with prostate cancer. Materials and methods: The concentrations of sex hormones, including testosterone (total, free, and bioavailable), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH), were measured in 415 patients diagnosed with prostate cancer. Differences in serum hormone concentrations after receiving androgen deprivation therapy (ADT) and after withdrawal from ADT were evaluated. Pathologic characteristics were assessed in the 225 patients unexposed to ADT with a history of radical prostatectomy. Logistic regression analysis was performed to identify factors predictive of unfavorable pathology (Grade ≥3, ≥T3a, or N1). Results: Of the 415 prostate cancer patients, 130 (31.3%) were assessed before treatment, 171 (41.2%) after surgery, 35 (8.4%) after biochemical recurrence, and 59 (14.2%) during ADT, whereas 20 (4.8%) had castration-resistant prostate cancer. FSH was significantly lower after compared to before prostatectomy (3.229 ± 4.486 vs. 5.941 ± 7.044 mIU/mL, p < 0.001). LH, FSH, and testosterone decreased significantly 3 months after starting ADT, but increased 3 months after ADT withdrawal, whereas SHBG was unchanged. Multivariate analysis showed that high LH (odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.03–2.47, p = 0.0376) and prostate-specific antigen (PSA) (OR: 1.13, 95% CI: 1.03–1.24, p = 0.0133) concentrations were significantly associated with a high risk of unfavorable pathology. Conclusions: Sex hormones, including LH, FSH, and testosterone, were affected by ADT. The FSH level decreased after radical prostatectomy. High baseline LH concentration in patients unexposed to ADT was associated with an unfavorable pathology. MDPI 2020-04-29 /pmc/articles/PMC7287653/ /pubmed/32365474 http://dx.doi.org/10.3390/jcm9051281 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Se Young
Chi, Byung Hoon
Lee, Wonchul
Lim, Bumjin
You, Dalsan
Kim, Choung-Soo
Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title_full Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title_fullStr Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title_full_unstemmed Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title_short Luteinizing Hormone Levels Relate to the Unfavorable Pathology of Prostate Cancer
title_sort luteinizing hormone levels relate to the unfavorable pathology of prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287653/
https://www.ncbi.nlm.nih.gov/pubmed/32365474
http://dx.doi.org/10.3390/jcm9051281
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