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Tyrosinase Inhibition and Kinetic Details of Puerol A Having But-2-Enolide Structure from Amorpha fruticosa

Puerol A (1) from Amorpha fruticosa showed highly potent inhibition against both monophenolase (IC(50) = 2.2 μM) and diphenolase (IC(50) = 3.8 μM) of tyrosinase. We tried to obtain a full story of enzyme inhibitory behavior for inhibitor 1 because the butenolide skeleton has never been reported as a...

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Detalles Bibliográficos
Autores principales: Kim, Jeong Ho, Jang, Da Hyun, Lee, Ki Won, Kim, Kwang Dong, Shah, Abdul Bari, Zhumanova, Kamila, Park, Ki Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287670/
https://www.ncbi.nlm.nih.gov/pubmed/32443441
http://dx.doi.org/10.3390/molecules25102344

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