Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs

Ruthenium-based complexes have received much interest as potential metallodrugs. In this work, four Ru(II) complexes bearing a dicarbollide moiety, a carbonyl ligand, and a phenanthroline-based ligand were synthesized and characterized, including single crystal diffraction analysis of compounds 2, 4...

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Autores principales: Kellert, Martin, Sárosi, Imola, Rajaratnam, Rajathees, Meggers, Eric, Lönnecke, Peter, Hey-Hawkins, Evamarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287719/
https://www.ncbi.nlm.nih.gov/pubmed/32429279
http://dx.doi.org/10.3390/molecules25102322
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author Kellert, Martin
Sárosi, Imola
Rajaratnam, Rajathees
Meggers, Eric
Lönnecke, Peter
Hey-Hawkins, Evamarie
author_facet Kellert, Martin
Sárosi, Imola
Rajaratnam, Rajathees
Meggers, Eric
Lönnecke, Peter
Hey-Hawkins, Evamarie
author_sort Kellert, Martin
collection PubMed
description Ruthenium-based complexes have received much interest as potential metallodrugs. In this work, four Ru(II) complexes bearing a dicarbollide moiety, a carbonyl ligand, and a phenanthroline-based ligand were synthesized and characterized, including single crystal diffraction analysis of compounds 2, 4, and 5 and an observed side product SP1. Complexes 2–5 are air and moisture stable under ambient conditions. They show excellent solubility in organic solvents, but low solubility in water.
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spelling pubmed-72877192020-06-15 Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs Kellert, Martin Sárosi, Imola Rajaratnam, Rajathees Meggers, Eric Lönnecke, Peter Hey-Hawkins, Evamarie Molecules Article Ruthenium-based complexes have received much interest as potential metallodrugs. In this work, four Ru(II) complexes bearing a dicarbollide moiety, a carbonyl ligand, and a phenanthroline-based ligand were synthesized and characterized, including single crystal diffraction analysis of compounds 2, 4, and 5 and an observed side product SP1. Complexes 2–5 are air and moisture stable under ambient conditions. They show excellent solubility in organic solvents, but low solubility in water. MDPI 2020-05-15 /pmc/articles/PMC7287719/ /pubmed/32429279 http://dx.doi.org/10.3390/molecules25102322 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kellert, Martin
Sárosi, Imola
Rajaratnam, Rajathees
Meggers, Eric
Lönnecke, Peter
Hey-Hawkins, Evamarie
Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title_full Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title_fullStr Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title_full_unstemmed Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title_short Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
title_sort ruthenacarborane–phenanthroline derivatives as potential metallodrugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287719/
https://www.ncbi.nlm.nih.gov/pubmed/32429279
http://dx.doi.org/10.3390/molecules25102322
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