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Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles

The fast-growing use of nanomaterials in everyday life raises the question about the safety of their use. Unfortunately, the risks associated with the use of nanoparticles (NPs) have not yet been fully assessed. The majority of studies conducted so far at the molecular and cellular level have focuse...

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Autores principales: Męczyńska-Wielgosz, Sylwia, Wojewódzka, Maria, Matysiak-Kucharek, Magdalena, Czajka, Magdalena, Jodłowska-Jędrych, Barbara, Kruszewski, Marcin, Kapka-Skrzypczak, Lucyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287770/
https://www.ncbi.nlm.nih.gov/pubmed/32408639
http://dx.doi.org/10.3390/ma13102221
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author Męczyńska-Wielgosz, Sylwia
Wojewódzka, Maria
Matysiak-Kucharek, Magdalena
Czajka, Magdalena
Jodłowska-Jędrych, Barbara
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
author_facet Męczyńska-Wielgosz, Sylwia
Wojewódzka, Maria
Matysiak-Kucharek, Magdalena
Czajka, Magdalena
Jodłowska-Jędrych, Barbara
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
author_sort Męczyńska-Wielgosz, Sylwia
collection PubMed
description The fast-growing use of nanomaterials in everyday life raises the question about the safety of their use. Unfortunately, the risks associated with the use of nanoparticles (NPs) have not yet been fully assessed. The majority of studies conducted so far at the molecular and cellular level have focused on a single-type exposure, assuming that NPs act as the only factor. In the natural environment, however, we are likely exposed to a mixture of nanoparticles, whose interactions may modulate their impact on living organisms. This study aimed to evaluate the toxicological effects caused by in vitro exposure of HepG2 cells to AgNPs in combination with AuNPs, CdTe quantum dot (QD) NPs, TiO(2)NPs, or SiO(2)NPs. The results showed that the toxicity of nanoparticle binary mixtures depended on the type and ratio of NPs used. In general, the toxicity of binary mixtures of NPs was lower than the sum of toxicities of NPs alone (protective effect).
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spelling pubmed-72877702020-06-15 Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles Męczyńska-Wielgosz, Sylwia Wojewódzka, Maria Matysiak-Kucharek, Magdalena Czajka, Magdalena Jodłowska-Jędrych, Barbara Kruszewski, Marcin Kapka-Skrzypczak, Lucyna Materials (Basel) Article The fast-growing use of nanomaterials in everyday life raises the question about the safety of their use. Unfortunately, the risks associated with the use of nanoparticles (NPs) have not yet been fully assessed. The majority of studies conducted so far at the molecular and cellular level have focused on a single-type exposure, assuming that NPs act as the only factor. In the natural environment, however, we are likely exposed to a mixture of nanoparticles, whose interactions may modulate their impact on living organisms. This study aimed to evaluate the toxicological effects caused by in vitro exposure of HepG2 cells to AgNPs in combination with AuNPs, CdTe quantum dot (QD) NPs, TiO(2)NPs, or SiO(2)NPs. The results showed that the toxicity of nanoparticle binary mixtures depended on the type and ratio of NPs used. In general, the toxicity of binary mixtures of NPs was lower than the sum of toxicities of NPs alone (protective effect). MDPI 2020-05-12 /pmc/articles/PMC7287770/ /pubmed/32408639 http://dx.doi.org/10.3390/ma13102221 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Męczyńska-Wielgosz, Sylwia
Wojewódzka, Maria
Matysiak-Kucharek, Magdalena
Czajka, Magdalena
Jodłowska-Jędrych, Barbara
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title_full Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title_fullStr Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title_full_unstemmed Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title_short Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
title_sort susceptibility of hepg2 cells to silver nanoparticles in combination with other metal/metal oxide nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287770/
https://www.ncbi.nlm.nih.gov/pubmed/32408639
http://dx.doi.org/10.3390/ma13102221
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