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Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials

The mushroom Agaricus bisporus secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from A. bisporus are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on A. bisporus...

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Autores principales: Tirta Ismaya, Wangsa, Tjandrawinata, Raymond Rubianto, Rachmawati, Heni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287795/
https://www.ncbi.nlm.nih.gov/pubmed/32443732
http://dx.doi.org/10.3390/molecules25102368
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author Tirta Ismaya, Wangsa
Tjandrawinata, Raymond Rubianto
Rachmawati, Heni
author_facet Tirta Ismaya, Wangsa
Tjandrawinata, Raymond Rubianto
Rachmawati, Heni
author_sort Tirta Ismaya, Wangsa
collection PubMed
description The mushroom Agaricus bisporus secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from A. bisporus are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on A. bisporus lectins and lectin-like proteins. No therapeutic products derived from A. bisporus lectin (ABL) are available on the market despite its extensive exploration. Recently, A. bisporus mannose-binding protein (Abmb) was discovered. Its discovery enriches the information and increases the interest in proteins with therapeutic potential from this mushroom. Furthermore, the A. bisporus genome reveals the possible occurrence of other lectins in this mushroom that may also have therapeutic potential. Most of these putative lectins belong to the same lectin groups as ABL and Abmb. Their relationship is discussed. Particular attention is addressed to ABL and Abmb, which have been explored for their potential in medicinal or pharmaceutical applications. ABL and Abmb have anti-proliferative activities toward cancer cells and a stimulatory effect on the immune system. Possible scenarios for their use in therapy and modification are also presented.
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spelling pubmed-72877952020-06-15 Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials Tirta Ismaya, Wangsa Tjandrawinata, Raymond Rubianto Rachmawati, Heni Molecules Review The mushroom Agaricus bisporus secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from A. bisporus are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on A. bisporus lectins and lectin-like proteins. No therapeutic products derived from A. bisporus lectin (ABL) are available on the market despite its extensive exploration. Recently, A. bisporus mannose-binding protein (Abmb) was discovered. Its discovery enriches the information and increases the interest in proteins with therapeutic potential from this mushroom. Furthermore, the A. bisporus genome reveals the possible occurrence of other lectins in this mushroom that may also have therapeutic potential. Most of these putative lectins belong to the same lectin groups as ABL and Abmb. Their relationship is discussed. Particular attention is addressed to ABL and Abmb, which have been explored for their potential in medicinal or pharmaceutical applications. ABL and Abmb have anti-proliferative activities toward cancer cells and a stimulatory effect on the immune system. Possible scenarios for their use in therapy and modification are also presented. MDPI 2020-05-20 /pmc/articles/PMC7287795/ /pubmed/32443732 http://dx.doi.org/10.3390/molecules25102368 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tirta Ismaya, Wangsa
Tjandrawinata, Raymond Rubianto
Rachmawati, Heni
Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title_full Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title_fullStr Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title_full_unstemmed Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title_short Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials
title_sort lectins from the edible mushroom agaricus bisporus and their therapeutic potentials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287795/
https://www.ncbi.nlm.nih.gov/pubmed/32443732
http://dx.doi.org/10.3390/molecules25102368
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