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Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy depositio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287827/ https://www.ncbi.nlm.nih.gov/pubmed/32466140 http://dx.doi.org/10.3390/s20102987 |
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author | Otero, Jorge Felis, Ivan Herrero, Alicia Merchán, José A. Ardid, Miguel |
author_facet | Otero, Jorge Felis, Ivan Herrero, Alicia Merchán, José A. Ardid, Miguel |
author_sort | Otero, Jorge |
collection | PubMed |
description | A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy. |
format | Online Article Text |
id | pubmed-7287827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72878272020-06-15 Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † Otero, Jorge Felis, Ivan Herrero, Alicia Merchán, José A. Ardid, Miguel Sensors (Basel) Article A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy. MDPI 2020-05-25 /pmc/articles/PMC7287827/ /pubmed/32466140 http://dx.doi.org/10.3390/s20102987 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Otero, Jorge Felis, Ivan Herrero, Alicia Merchán, José A. Ardid, Miguel Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title | Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title_full | Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title_fullStr | Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title_full_unstemmed | Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title_short | Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † |
title_sort | bragg peak localization with piezoelectric sensors for proton therapy treatment † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287827/ https://www.ncbi.nlm.nih.gov/pubmed/32466140 http://dx.doi.org/10.3390/s20102987 |
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