Cargando…

Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †

A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy depositio...

Descripción completa

Detalles Bibliográficos
Autores principales: Otero, Jorge, Felis, Ivan, Herrero, Alicia, Merchán, José A., Ardid, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287827/
https://www.ncbi.nlm.nih.gov/pubmed/32466140
http://dx.doi.org/10.3390/s20102987
_version_ 1783545139594002432
author Otero, Jorge
Felis, Ivan
Herrero, Alicia
Merchán, José A.
Ardid, Miguel
author_facet Otero, Jorge
Felis, Ivan
Herrero, Alicia
Merchán, José A.
Ardid, Miguel
author_sort Otero, Jorge
collection PubMed
description A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy.
format Online
Article
Text
id pubmed-7287827
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72878272020-06-15 Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment † Otero, Jorge Felis, Ivan Herrero, Alicia Merchán, José A. Ardid, Miguel Sensors (Basel) Article A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy. MDPI 2020-05-25 /pmc/articles/PMC7287827/ /pubmed/32466140 http://dx.doi.org/10.3390/s20102987 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Otero, Jorge
Felis, Ivan
Herrero, Alicia
Merchán, José A.
Ardid, Miguel
Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title_full Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title_fullStr Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title_full_unstemmed Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title_short Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment †
title_sort bragg peak localization with piezoelectric sensors for proton therapy treatment †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287827/
https://www.ncbi.nlm.nih.gov/pubmed/32466140
http://dx.doi.org/10.3390/s20102987
work_keys_str_mv AT oterojorge braggpeaklocalizationwithpiezoelectricsensorsforprotontherapytreatment
AT felisivan braggpeaklocalizationwithpiezoelectricsensorsforprotontherapytreatment
AT herreroalicia braggpeaklocalizationwithpiezoelectricsensorsforprotontherapytreatment
AT merchanjosea braggpeaklocalizationwithpiezoelectricsensorsforprotontherapytreatment
AT ardidmiguel braggpeaklocalizationwithpiezoelectricsensorsforprotontherapytreatment