High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch

Riboswitches are important model systems for the development of approaches to search for RNA-targeting therapeutics. A principal challenge in finding compounds that target riboswitches is that the effector ligand is typically almost completely encapsulated by the RNA, which severely limits the chemi...

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Detalles Bibliográficos
Autores principales: Matyjasik, Michal M., Hall, Simone D., Batey, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287874/
https://www.ncbi.nlm.nih.gov/pubmed/32414072
http://dx.doi.org/10.3390/molecules25102295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287874/
https://www.ncbi.nlm.nih.gov/pubmed/32414072
http://dx.doi.org/10.3390/molecules25102295

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