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Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival

Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is...

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Autores principales: Schönberg, Alfrun, Hamdorf, Matthias, Bock, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287922/
https://www.ncbi.nlm.nih.gov/pubmed/32354200
http://dx.doi.org/10.3390/jcm9051280
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author Schönberg, Alfrun
Hamdorf, Matthias
Bock, Felix
author_facet Schönberg, Alfrun
Hamdorf, Matthias
Bock, Felix
author_sort Schönberg, Alfrun
collection PubMed
description Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation’s resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation.
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spelling pubmed-72879222020-06-15 Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival Schönberg, Alfrun Hamdorf, Matthias Bock, Felix J Clin Med Review Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation’s resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation. MDPI 2020-04-28 /pmc/articles/PMC7287922/ /pubmed/32354200 http://dx.doi.org/10.3390/jcm9051280 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schönberg, Alfrun
Hamdorf, Matthias
Bock, Felix
Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title_full Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title_fullStr Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title_full_unstemmed Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title_short Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
title_sort immunomodulatory strategies targeting dendritic cells to improve corneal graft survival
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287922/
https://www.ncbi.nlm.nih.gov/pubmed/32354200
http://dx.doi.org/10.3390/jcm9051280
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