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Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival
Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287922/ https://www.ncbi.nlm.nih.gov/pubmed/32354200 http://dx.doi.org/10.3390/jcm9051280 |
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author | Schönberg, Alfrun Hamdorf, Matthias Bock, Felix |
author_facet | Schönberg, Alfrun Hamdorf, Matthias Bock, Felix |
author_sort | Schönberg, Alfrun |
collection | PubMed |
description | Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation’s resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation. |
format | Online Article Text |
id | pubmed-7287922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72879222020-06-15 Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival Schönberg, Alfrun Hamdorf, Matthias Bock, Felix J Clin Med Review Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since blood and lymphatic vessels have been identified as a severe risk factor for corneal allograft survival, much research has focused on vessel regression or inhibition of hem- and lymphangiogenesis in general. However, lymphatic vessels have been identified as required for the inflammation’s resolution. Therefore, targeting other players of corneal engraftment could reveal new therapeutic strategies. The establishment of a tolerogenic microenvironment at the graft site would leave the recipient with the ability to manage pathogenic conditions independent from transplantation. Dendritic cells (DCs) as the central player of the immune system represent a target that allows the induction of tolerogenic mechanisms by many different strategies. These strategies are reviewed in this article with regard to their success in corneal transplantation. MDPI 2020-04-28 /pmc/articles/PMC7287922/ /pubmed/32354200 http://dx.doi.org/10.3390/jcm9051280 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schönberg, Alfrun Hamdorf, Matthias Bock, Felix Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title | Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title_full | Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title_fullStr | Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title_full_unstemmed | Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title_short | Immunomodulatory Strategies Targeting Dendritic Cells to Improve Corneal Graft Survival |
title_sort | immunomodulatory strategies targeting dendritic cells to improve corneal graft survival |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287922/ https://www.ncbi.nlm.nih.gov/pubmed/32354200 http://dx.doi.org/10.3390/jcm9051280 |
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