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Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex
Background: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort. Methods: A random sample of 4057 dementia-free community participants aged 55 or older, from the longitudinal, community-based Zaragoza Dement...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287941/ https://www.ncbi.nlm.nih.gov/pubmed/32366003 http://dx.doi.org/10.3390/brainsci10050265 |
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author | Santabárbara, Javier Villagrasa, Beatriz Lopez-Anton, Raúl la Cámara, Concepción De Gracia-García, Patricia Lobo, Antonio |
author_facet | Santabárbara, Javier Villagrasa, Beatriz Lopez-Anton, Raúl la Cámara, Concepción De Gracia-García, Patricia Lobo, Antonio |
author_sort | Santabárbara, Javier |
collection | PubMed |
description | Background: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort. Methods: A random sample of 4057 dementia-free community participants aged 55 or older, from the longitudinal, community-based Zaragoza Dementia and Depression Project (ZARADEMP) study were followed for 4.5 years. Geriatric Mental State B (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) was used for the assessment and diagnosis of anxiety, and a panel of research psychiatrists diagnosed the incident cases of VaD according to DSM-IV (Diagnostic and Statistical Manual of mental disordes). Multivariate survival analysis with competing risk regression model was performed. Results: In men, the incidence rate of VaD was significantly higher among anxiety subjects compared with non-anxiety subjects (incidence rate ratio (IRR) (95% confidence interval (CI)): 3.24 (1.13–9.35); p = 0.029), and no difference was observed in women (IRR (95%CI): 0.68 (0.19–2.23); p = 0.168). In the multivariate model, for men, cases of anxiety had 2.6-fold higher risk of VaD (subdistribution hazard ratio (SHR): 2.61; 95%CI: 0.88–7.74) when all potential confounding factors were controlled, with no statistical significance (p = 0.084), but a clinically relevant effect (Cohen’s d: 0.74). No association was found in women. Conclusions: In men, but not in women, risk of VaD was higher among individuals with anxiety, with a clinically relevant effect. Potential anxiety-related preventive interventions for VaD might be tailored to men and women separately. |
format | Online Article Text |
id | pubmed-7287941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72879412020-06-15 Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex Santabárbara, Javier Villagrasa, Beatriz Lopez-Anton, Raúl la Cámara, Concepción De Gracia-García, Patricia Lobo, Antonio Brain Sci Article Background: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort. Methods: A random sample of 4057 dementia-free community participants aged 55 or older, from the longitudinal, community-based Zaragoza Dementia and Depression Project (ZARADEMP) study were followed for 4.5 years. Geriatric Mental State B (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) was used for the assessment and diagnosis of anxiety, and a panel of research psychiatrists diagnosed the incident cases of VaD according to DSM-IV (Diagnostic and Statistical Manual of mental disordes). Multivariate survival analysis with competing risk regression model was performed. Results: In men, the incidence rate of VaD was significantly higher among anxiety subjects compared with non-anxiety subjects (incidence rate ratio (IRR) (95% confidence interval (CI)): 3.24 (1.13–9.35); p = 0.029), and no difference was observed in women (IRR (95%CI): 0.68 (0.19–2.23); p = 0.168). In the multivariate model, for men, cases of anxiety had 2.6-fold higher risk of VaD (subdistribution hazard ratio (SHR): 2.61; 95%CI: 0.88–7.74) when all potential confounding factors were controlled, with no statistical significance (p = 0.084), but a clinically relevant effect (Cohen’s d: 0.74). No association was found in women. Conclusions: In men, but not in women, risk of VaD was higher among individuals with anxiety, with a clinically relevant effect. Potential anxiety-related preventive interventions for VaD might be tailored to men and women separately. MDPI 2020-04-30 /pmc/articles/PMC7287941/ /pubmed/32366003 http://dx.doi.org/10.3390/brainsci10050265 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Santabárbara, Javier Villagrasa, Beatriz Lopez-Anton, Raúl la Cámara, Concepción De Gracia-García, Patricia Lobo, Antonio Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title | Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title_full | Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title_fullStr | Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title_full_unstemmed | Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title_short | Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex |
title_sort | anxiety and risk of vascular dementia in an elderly community sample: the role of sex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287941/ https://www.ncbi.nlm.nih.gov/pubmed/32366003 http://dx.doi.org/10.3390/brainsci10050265 |
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