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Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases. The exact nature of these cleavage sites, an...
Autores principales: | Barile, Elisa, Baggio, Carlo, Gambini, Luca, Shiryaev, Sergey A., Strongin, Alex Y., Pellecchia, Maurizio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287953/ https://www.ncbi.nlm.nih.gov/pubmed/32455942 http://dx.doi.org/10.3390/molecules25102424 |
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