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Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and thos...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287970/ https://www.ncbi.nlm.nih.gov/pubmed/32354006 http://dx.doi.org/10.3390/jcm9051271 |
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author | Kedar Sade, Eliel Wainstock, Tamar Tsumi, Erez Sheiner, Eyal |
author_facet | Kedar Sade, Eliel Wainstock, Tamar Tsumi, Erez Sheiner, Eyal |
author_sort | Kedar Sade, Eliel |
collection | PubMed |
description | The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and those who were not. The study population was composed of children who were born between the years 1991 and 2014 at a single tertiary medical center. Total ophthalmic hospitalization and time-to-event were both evaluated. A Kaplan–Meier survival curve was conducted to compare cumulative ophthalmic hospitalization incidence based on the severity of preeclampsia. Confounders were controlled using a Cox regression model. A total of 242,342 deliveries met the inclusion criteria, of which 7279 (3%) were diagnosed with mild preeclampsia and 2222 (0.92%) with severe preeclampsia or eclampsia. A significant association was found between severe preeclampsia or eclampsia and the risk of long-term vascular-associated ophthalmic morbidity in the offspring (no preeclampsia 0.3%, mild preeclampsia 0.2% and severe preeclampsia or eclampsia 0.5%, p = 0.008). This association persisted after controlling for maternal age and ethnicity (adjusted hazard ratio (HR) 1.861, 95% CI 1.051–3.295). In conclusion, within our population, prenatal exposure to severe preeclampsia or eclampsia was found to be a risk factor for long-term vascular-associated ophthalmic morbidity in the offspring. |
format | Online Article Text |
id | pubmed-7287970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72879702020-06-15 Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring Kedar Sade, Eliel Wainstock, Tamar Tsumi, Erez Sheiner, Eyal J Clin Med Article The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and those who were not. The study population was composed of children who were born between the years 1991 and 2014 at a single tertiary medical center. Total ophthalmic hospitalization and time-to-event were both evaluated. A Kaplan–Meier survival curve was conducted to compare cumulative ophthalmic hospitalization incidence based on the severity of preeclampsia. Confounders were controlled using a Cox regression model. A total of 242,342 deliveries met the inclusion criteria, of which 7279 (3%) were diagnosed with mild preeclampsia and 2222 (0.92%) with severe preeclampsia or eclampsia. A significant association was found between severe preeclampsia or eclampsia and the risk of long-term vascular-associated ophthalmic morbidity in the offspring (no preeclampsia 0.3%, mild preeclampsia 0.2% and severe preeclampsia or eclampsia 0.5%, p = 0.008). This association persisted after controlling for maternal age and ethnicity (adjusted hazard ratio (HR) 1.861, 95% CI 1.051–3.295). In conclusion, within our population, prenatal exposure to severe preeclampsia or eclampsia was found to be a risk factor for long-term vascular-associated ophthalmic morbidity in the offspring. MDPI 2020-04-28 /pmc/articles/PMC7287970/ /pubmed/32354006 http://dx.doi.org/10.3390/jcm9051271 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kedar Sade, Eliel Wainstock, Tamar Tsumi, Erez Sheiner, Eyal Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title | Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title_full | Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title_fullStr | Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title_full_unstemmed | Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title_short | Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring |
title_sort | prenatal exposure to preeclampsia and long-term ophthalmic morbidity of the offspring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287970/ https://www.ncbi.nlm.nih.gov/pubmed/32354006 http://dx.doi.org/10.3390/jcm9051271 |
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