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Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring

The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and thos...

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Autores principales: Kedar Sade, Eliel, Wainstock, Tamar, Tsumi, Erez, Sheiner, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287970/
https://www.ncbi.nlm.nih.gov/pubmed/32354006
http://dx.doi.org/10.3390/jcm9051271
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author Kedar Sade, Eliel
Wainstock, Tamar
Tsumi, Erez
Sheiner, Eyal
author_facet Kedar Sade, Eliel
Wainstock, Tamar
Tsumi, Erez
Sheiner, Eyal
author_sort Kedar Sade, Eliel
collection PubMed
description The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and those who were not. The study population was composed of children who were born between the years 1991 and 2014 at a single tertiary medical center. Total ophthalmic hospitalization and time-to-event were both evaluated. A Kaplan–Meier survival curve was conducted to compare cumulative ophthalmic hospitalization incidence based on the severity of preeclampsia. Confounders were controlled using a Cox regression model. A total of 242,342 deliveries met the inclusion criteria, of which 7279 (3%) were diagnosed with mild preeclampsia and 2222 (0.92%) with severe preeclampsia or eclampsia. A significant association was found between severe preeclampsia or eclampsia and the risk of long-term vascular-associated ophthalmic morbidity in the offspring (no preeclampsia 0.3%, mild preeclampsia 0.2% and severe preeclampsia or eclampsia 0.5%, p = 0.008). This association persisted after controlling for maternal age and ethnicity (adjusted hazard ratio (HR) 1.861, 95% CI 1.051–3.295). In conclusion, within our population, prenatal exposure to severe preeclampsia or eclampsia was found to be a risk factor for long-term vascular-associated ophthalmic morbidity in the offspring.
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spelling pubmed-72879702020-06-15 Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring Kedar Sade, Eliel Wainstock, Tamar Tsumi, Erez Sheiner, Eyal J Clin Med Article The aim of this population-based study was to evaluate whether prenatal exposure to preeclampsia poses a risk for long-term ophthalmic morbidity. A population-based cohort analysis compared the risk of long-term ophthalmic morbidity among children who were prenatally exposed to preeclampsia and those who were not. The study population was composed of children who were born between the years 1991 and 2014 at a single tertiary medical center. Total ophthalmic hospitalization and time-to-event were both evaluated. A Kaplan–Meier survival curve was conducted to compare cumulative ophthalmic hospitalization incidence based on the severity of preeclampsia. Confounders were controlled using a Cox regression model. A total of 242,342 deliveries met the inclusion criteria, of which 7279 (3%) were diagnosed with mild preeclampsia and 2222 (0.92%) with severe preeclampsia or eclampsia. A significant association was found between severe preeclampsia or eclampsia and the risk of long-term vascular-associated ophthalmic morbidity in the offspring (no preeclampsia 0.3%, mild preeclampsia 0.2% and severe preeclampsia or eclampsia 0.5%, p = 0.008). This association persisted after controlling for maternal age and ethnicity (adjusted hazard ratio (HR) 1.861, 95% CI 1.051–3.295). In conclusion, within our population, prenatal exposure to severe preeclampsia or eclampsia was found to be a risk factor for long-term vascular-associated ophthalmic morbidity in the offspring. MDPI 2020-04-28 /pmc/articles/PMC7287970/ /pubmed/32354006 http://dx.doi.org/10.3390/jcm9051271 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kedar Sade, Eliel
Wainstock, Tamar
Tsumi, Erez
Sheiner, Eyal
Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title_full Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title_fullStr Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title_full_unstemmed Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title_short Prenatal Exposure to Preeclampsia and Long-Term Ophthalmic Morbidity of the Offspring
title_sort prenatal exposure to preeclampsia and long-term ophthalmic morbidity of the offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287970/
https://www.ncbi.nlm.nih.gov/pubmed/32354006
http://dx.doi.org/10.3390/jcm9051271
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