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Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses
We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOA...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287991/ https://www.ncbi.nlm.nih.gov/pubmed/32443914 http://dx.doi.org/10.3390/molecules25102379 |
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author | Kim, Chae Hyun Kim, Jung-Eun Song, Yoon-Jae |
author_facet | Kim, Chae Hyun Kim, Jung-Eun Song, Yoon-Jae |
author_sort | Kim, Chae Hyun |
collection | PubMed |
description | We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOAc fraction of ESE that inhibits VZV but not HCMV replication. In this study, we comprehensively screened the chemical compounds identified in the EtOAc fraction of ESE for potential antiviral properties. Among the examined compounds, quercetin and isoquercitrin displayed potent antiviral activities against both VZV and HCMV with no significant cytotoxic effects. Both compounds strongly suppressed the expression of VZV and HCMV immediate–early (IE) genes. Our collective results indicated that, in addition to PGG, quercetin and isoquercitrin are bioactive compounds in the EtOAc fraction of ESE that effectively inhibit human herpesvirus replication. |
format | Online Article Text |
id | pubmed-7287991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72879912020-06-15 Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses Kim, Chae Hyun Kim, Jung-Eun Song, Yoon-Jae Molecules Article We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOAc fraction of ESE that inhibits VZV but not HCMV replication. In this study, we comprehensively screened the chemical compounds identified in the EtOAc fraction of ESE for potential antiviral properties. Among the examined compounds, quercetin and isoquercitrin displayed potent antiviral activities against both VZV and HCMV with no significant cytotoxic effects. Both compounds strongly suppressed the expression of VZV and HCMV immediate–early (IE) genes. Our collective results indicated that, in addition to PGG, quercetin and isoquercitrin are bioactive compounds in the EtOAc fraction of ESE that effectively inhibit human herpesvirus replication. MDPI 2020-05-20 /pmc/articles/PMC7287991/ /pubmed/32443914 http://dx.doi.org/10.3390/molecules25102379 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Chae Hyun Kim, Jung-Eun Song, Yoon-Jae Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title | Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title_full | Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title_fullStr | Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title_full_unstemmed | Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title_short | Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses |
title_sort | antiviral activities of quercetin and isoquercitrin against human herpesviruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287991/ https://www.ncbi.nlm.nih.gov/pubmed/32443914 http://dx.doi.org/10.3390/molecules25102379 |
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