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Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica
Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-in...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288028/ https://www.ncbi.nlm.nih.gov/pubmed/32443866 http://dx.doi.org/10.3390/molecules25102372 |
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author | Gainche, Maël Ripoche, Isabelle Senejoux, François Cholet, Juliette Ogeron, Clémence Decombat, Caroline Danton, Ombeline Delort, Laetitia Vareille-Delarbre, Marjolaine Berry, Alexandre Vermerie, Marion Fraisse, Didier Felgines, Catherine Ranouille, Edwige Berthon, Jean-Yves Priam, Julien Saunier, Etienne Tourrette, Albert Troin, Yves Caldefie-Chezet, Florence Chalard, Pierre |
author_facet | Gainche, Maël Ripoche, Isabelle Senejoux, François Cholet, Juliette Ogeron, Clémence Decombat, Caroline Danton, Ombeline Delort, Laetitia Vareille-Delarbre, Marjolaine Berry, Alexandre Vermerie, Marion Fraisse, Didier Felgines, Catherine Ranouille, Edwige Berthon, Jean-Yves Priam, Julien Saunier, Etienne Tourrette, Albert Troin, Yves Caldefie-Chezet, Florence Chalard, Pierre |
author_sort | Gainche, Maël |
collection | PubMed |
description | Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. Luzula sylvatica, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of L. sylvatica aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin 1 and eight phenanthrene derivatives (2–9), including four new compounds (4, 5, 8 and 9), from n-hexane and CH(2)Cl(2), fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives 4, 6, and 7 showed very promising antiproliferative activities. |
format | Online Article Text |
id | pubmed-7288028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72880282020-06-15 Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica Gainche, Maël Ripoche, Isabelle Senejoux, François Cholet, Juliette Ogeron, Clémence Decombat, Caroline Danton, Ombeline Delort, Laetitia Vareille-Delarbre, Marjolaine Berry, Alexandre Vermerie, Marion Fraisse, Didier Felgines, Catherine Ranouille, Edwige Berthon, Jean-Yves Priam, Julien Saunier, Etienne Tourrette, Albert Troin, Yves Caldefie-Chezet, Florence Chalard, Pierre Molecules Article Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti-microbial, spasmolytic, and anti-inflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti-inflammatory and cytotoxic properties. Luzula sylvatica, a Juncaceae species, is widely present in the Auvergne region of France, but has never been studied neither for its phytochemical profile nor for its biological properties. We investigated the phytochemical profile and evaluated the potential anti-inflammatory activities of L. sylvatica aerial parts extracts. A bioassay-guided fractionation was carried out to identify the most active fractions. Nine compounds were isolated, one coumarin 1 and eight phenanthrene derivatives (2–9), including four new compounds (4, 5, 8 and 9), from n-hexane and CH(2)Cl(2), fractions. Their structures were established by HRESIMS, 1D and 2D NMR experiments. The biological properties, especially the anti-inflammatory/antioxidant activities (ROS production) and antiproliferative activity on THP-1, a monocytic leukemia cell line, of each compound, were evaluated. Three phenanthrene derivatives 4, 6, and 7 showed very promising antiproliferative activities. MDPI 2020-05-20 /pmc/articles/PMC7288028/ /pubmed/32443866 http://dx.doi.org/10.3390/molecules25102372 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gainche, Maël Ripoche, Isabelle Senejoux, François Cholet, Juliette Ogeron, Clémence Decombat, Caroline Danton, Ombeline Delort, Laetitia Vareille-Delarbre, Marjolaine Berry, Alexandre Vermerie, Marion Fraisse, Didier Felgines, Catherine Ranouille, Edwige Berthon, Jean-Yves Priam, Julien Saunier, Etienne Tourrette, Albert Troin, Yves Caldefie-Chezet, Florence Chalard, Pierre Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title_full | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title_fullStr | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title_full_unstemmed | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title_short | Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica |
title_sort | anti-inflammatory and cytotoxic potential of new phenanthrenoids from luzula sylvatica |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288028/ https://www.ncbi.nlm.nih.gov/pubmed/32443866 http://dx.doi.org/10.3390/molecules25102372 |
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