Cargando…

Anti-aggregation Effects of Phenolic Compounds on α-synuclein

The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ono, Kenjiro, Tsuji, Mayumi, Yamasaki, Tritia R., Pasinetti, Giulio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288075/ https://www.ncbi.nlm.nih.gov/pubmed/32456274 http://dx.doi.org/10.3390/molecules25102444

Ejemplares similares

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
por: Yamasaki, Tritia R., et al.
Publicado: (2020)

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro
por: Ibrahim, Nor Faeizah, et al.
Publicado: (2021)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

The Effects of Lipids on α-Synuclein Aggregation In Vitro
por: Ramirez, Jennifer, et al.
Publicado: (2023)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
por: Herva, Maria Eugenia, et al.
Publicado: (2014)

Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics
por: Yamasaki, Tritia R., et al.
Publicado: (2019)

Initiation and propagation of α-synuclein aggregation in the nervous system
por: Hijaz, Baraa A., et al.
Publicado: (2020)

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2015)

One ring is sufficient to inhibit α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2021)

The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics
por: Noguchi-Shinohara, Moeko, et al.
Publicado: (2023)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease
por: Ono, Kenjiro, et al.
Publicado: (2020)

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
por: Gracia, Pablo, et al.
Publicado: (2020)

Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity
por: Jha, Narendra Nath, et al.
Publicado: (2016)

Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane
por: Ito, Naohito, et al.
Publicado: (2023)

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
por: Roostaee, Alireza, et al.
Publicado: (2013)

Sumoylation inhibits α-synuclein aggregation and toxicity
por: Krumova, Petranka, et al.
Publicado: (2011)

In vitro aggregation assays for the characterization of α-synuclein prion-like properties
por: Narkiewicz, Joanna, et al.
Publicado: (2014)

Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
por: Kim, Beom Jin, et al.
Publicado: (2023)

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds
por: Stefani, Massimo, et al.
Publicado: (2013)

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization
por: Dominguez-Meijide, Antonio, et al.
Publicado: (2020)

Molecular Topology as Novel Strategy for Discovery of Drugs with Aβ Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease
por: Wang, Jun, et al.
Publicado: (2014)

Mechanism of Anti-α-Synuclein Immunotherapy
por: Lee, Jun Sung, et al.
Publicado: (2016)

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein
por: Leitao, Andre, et al.
Publicado: (2018)

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
por: Scheibe, Christian, et al.
Publicado: (2021)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
por: Hellstrand, Erik, et al.
Publicado: (2013)

Human pericytes degrade diverse α-synuclein aggregates
por: Dieriks, Birger Victor, et al.
Publicado: (2022)

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization
por: Peña-Díaz, Samuel, et al.
Publicado: (2019)

Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation
por: Lin, Yuxi, et al.
Publicado: (2022)

Computational insights into the role of α-strand/sheet in aggregation of α-synuclein
por: Balupuri, Anand, et al.
Publicado: (2019)

Hyperosmotic stress induces cell-dependent aggregation of α-synuclein
por: Fragniere, Alexandra M. C., et al.
Publicado: (2019)

Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease
por: Basu, Sambuddha, et al.
Publicado: (2015)

Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism
por: Uversky, Vladimir N.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_huppcpnljb7ns4t5qmhr3bhu3l