Cargando…

Virtual Screening and the In Vitro Assessment of the Antileishmanial Activity of Lignans

Leishmaniasis is endemic in at least 98 countries. Due to the high toxicity and resistance associated with the drugs, we chose lignans as an alternative, due to their favorable properties of absorption, distribution, metabolism, excretion, and toxicity (ADMET). To investigate their leishmanicidal po...

Descripción completa

Detalles Bibliográficos
Autores principales:	dos Santos Maia, Mayara, Raimundo e Silva, Joanda Paolla, de Lima Nunes, Thaís Amanda, Saraiva de Sousa, Julyanne Maria, Soares Rodrigues, Gabriela Cristina, Messias Monteiro, Alex France, Fechine Tavares, Josean, da Franca Rodrigues, Klinger Antonio, B. Mendonça-Junior, Francisco Jaime, Scotti, Luciana, Scotti, Marcus Tullius
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288103/ https://www.ncbi.nlm.nih.gov/pubmed/32408657 http://dx.doi.org/10.3390/molecules25102281

Ejemplares similares

Identification of New Targets and the Virtual Screening of Lignans against Alzheimer's Disease
por: dos Santos Maia, Mayara, et al.
Publicado: (2020)

Virtual Screening of Different Subclasses of Lignans with Anticancer Potential and Based on Genetic Profile
por: Maia, Mayara dos Santos, et al.
Publicado: (2023)

Computer-Aided Chemotaxonomy and Bioprospecting Study of Diterpenes of the Lamiaceae Family
por: Barbosa Silva Cavalcanti, Andreza, et al.
Publicado: (2019)

Cytotoxic and Antileishmanial Effects of the Monoterpene β-Ocimene
por: de Sousa, Julyanne Maria Saraiva, et al.
Publicado: (2023)

In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential against Aphis gossypii and Drosophila melanogaster
por: Rodrigues, Gabriela Cristina Soares, et al.
Publicado: (2021)

Mass Spectrometry-Based Investigation of Sugarcane Exposed to Five Different Pesticides
por: de Souza, Thalisson A., et al.
Publicado: (2023)

Computer Aided Drug Design Methodologies with Natural Products in the Drug Research Against Alzheimer’s Disease
por: de Sousa, Natália Ferreira, et al.
Publicado: (2022)

Cleomin Exerts Acute Antinociceptive Effects in Mice via GABA(B) and Muscarinic Receptors
por: Opretzka, Luíza Carolina França, et al.
Publicado: (2023)

Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases
por: Monteiro, Alex France M., et al.
Publicado: (2018)

Dolichocarpols A-F, Unprecedented Macrocyclic Humulene-Type Sesquiterpenoids from Anaxagorea dolichocarpa
por: Sales, Kaio Aragão, et al.
Publicado: (2020)

Docking Prediction, Antifungal Activity, Anti-Biofilm Effects on Candida spp., and Toxicity against Human Cells of Cinnamaldehyde
por: da Nóbrega Alves, Danielle, et al.
Publicado: (2020)

Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases 2020
por: Mendonça-Junior, Francisco Jaime Bezerra, et al.
Publicado: (2021)

Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses
por: Luna, Emanuela Coutinho, et al.
Publicado: (2019)

Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis
por: Golzio dos Santos, Sócrates, et al.
Publicado: (2020)

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
por: Ferreira, Rafael Carlos, et al.
Publicado: (2023)

Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents
por: de Sousa, Natália Ferreira, et al.
Publicado: (2023)

Antimicrobial Potential of Betulinic Acid and Investigation of the Mechanism of Action against Nuclear and Metabolic Enzymes with Molecular Modeling
por: Rodrigues, Gabriela Cristina Soares, et al.
Publicado: (2023)

ISCOM-Matrices Nanoformulation Using the Raw Aqueous Extract of Quillaja lancifolia (Q. brasiliensis)
por: Cibulski, Samuel, et al.
Publicado: (2022)

Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2021)

Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity
por: de Menezes, Renata Priscila Barros, et al.
Publicado: (2022)

Chemometric Studies on Natural Products as Potential Inhibitors of the NADH Oxidase from Trypanosoma cruzi Using the VolSurf Approach
por: Scotti, Luciana, et al.
Publicado: (2010)

Computer-Aided Drug Design Using Sesquiterpene Lactones as Sources of New Structures with Potential Activity against Infectious Neglected Diseases
por: Herrera Acevedo, Chonny, et al.
Publicado: (2017)

Antibacterial Activity and Anxiolytic Effect in Adult Zebrafish of Genus Lippia L. Species
por: Nonato, Carla de Fatima Alves, et al.
Publicado: (2023)

Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review
por: Assis, Davidson Barbosa, et al.
Publicado: (2020)

Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity
por: de Araújo, Rodrigo S. A., et al.
Publicado: (2013)

SistematX, an Online Web-Based Cheminformatics Tool for Data Management of Secondary Metabolites
por: Scotti, Marcus Tullius, et al.
Publicado: (2018)

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2023)

Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites
por: Barros de Menezes, Renata Priscila, et al.
Publicado: (2022)

Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies
por: Leite, Fernando Ferreira, et al.
Publicado: (2023)

Antileishmanial Activity of Cinnamic Acid Derivatives against Leishmania infantum
por: de Morais, Mayara Castro, et al.
Publicado: (2023)

Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning
por: Moreira, Laysa Lanes Pereira Ferreira, et al.
Publicado: (2022)

In vivo antileishmanial activity and chemical profile of polar extract from Selaginella sellowii
por: Queiroz, Dayane Priscilla de Souza, et al.
Publicado: (2016)

Lignans
por: Barker, David
Publicado: (2019)

Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins
por: Rodrigues, Igor A., et al.
Publicado: (2018)

4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
por: Rodrigues, Carina Agostinho, et al.
Publicado: (2018)

Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives
por: de Araújo, Rodrigo Santos Aquino, et al.
Publicado: (2016)

Design and Synthesis of New Anthranyl Phenylhydrazides: Antileishmanial Activity and Structure–Activity Relationship
por: do Carmo Maquiaveli, Claudia, et al.
Publicado: (2023)

Bioactive Essential Oils from Cuban Plants: An Inspiration to Drug Development
por: Monzote, Lianet, et al.
Publicado: (2021)

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment
por: Ali, Imran, et al.
Publicado: (2020)

Antileishmanial activity of the essential oil from Tetradenia riparia obtained in different seasons
por: Cardoso, Bruna Muller, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4g613ir8g8lf1b777rofmg4j8u