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The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork progression. ICL accumulation results in growth arrest and cell death—particularly in cell populations undergoing high replicative activity, such as cancer and leukemic cells. For this reason, agents able to i...

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Detalles Bibliográficos
Autores principales:	Renaudin, Xavier, Rosselli, Filippo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288313/ https://www.ncbi.nlm.nih.gov/pubmed/32466131 http://dx.doi.org/10.3390/genes11050585

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